Netupitant Impurity 27 CAS 2920686-87-7
| CAS No. | 2920686-87-7 |
| Molecular Formula | C23H16F12O4 |
| Molecular Weight | 584.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Netupitant Impurity 27 (C23H16F12O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Netupitant Impurity 27 (CAS 2920686-87-7) is a certified pharmaceutical impurity reference standard with the molecular formula C23H16F12O4 and a molecular weight of 584.35 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Netupitant Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H16F12O4 |
| Molecular Weight | 584.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | F-containing |
Related Netupitant Standards
- Netupitant-d6 (CAS 2070015-31-3)
- Netupitant (CAS 290297-26-6)
- Netupitant Impurity 14 (CAS CATO-C4X-122314)
- Netupitant Impurity 59 (CAS CATO-C4X-122359)
- Netupitant Impurity 53 (CAS CATO-C4X-122353)
- Netupitant Impurity 48 (CAS CATO-C4X-122348)
- Netupitant Impurity 39 (CAS CATO-C4X-122339)
- Netupitant Impurity N1 (CAS 910808-12-7)
Recommended Standards
- Br-PEG9-CH2CH2Br (CAS 140714-66-5)
- 2,2'-((2,2-Diphenylethene-1,1-diyl)bis(4,1-phenylene))bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 1447669-03-5)
- N-(3-Dimethylaminopropyl)perfluorooctanesulfonamide (CAS 13417-01-1)
- 1,2-Diphenyl-1,2-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethene (CAS 2095541-89-0)
- Ivacaftor Impurity 13 (CAS 529-37-3)
- Lisinopril Impurity 13 (CAS CATO-C4X-168113)
- Tofacitinib Impurity 76 (CAS CATO-C4X-107976)
- 2-Fluoro-N-methyl-5-nitrobenzenesulfonamide (CAS 1094853-29-8)
- 1-Bromo-3-propoxycyclobutane (CAS 1516177-37-9)
- Lotilaner Impurity 10 (CAS CATO-C4X-325610)
- (2R,3R)-Diethyl piperazine-2,3-dicarboxylate (CAS 1279049-70-5)
- 4-(3,4,5-Trimethoxyphenyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine (CAS 4875-50-7)
- 3-((1H-benzo[d]imidazol-2-yl)thio)-1,1,1-trifluoropropan-2-ol (CAS 1490488-25-9)
- Glucagon Monohydrochloride (CAS 28270-04-4)
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