Resmetirom Impurity 40 CAS 2947651-03-6
| CAS No. | 2947651-03-6 |
| Molecular Formula | C15H14Cl3N3O2 |
| Molecular Weight | 374.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Resmetirom Impurity 40 (C15H14Cl3N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Resmetirom Impurity 40 (CAS 2947651-03-6, C15H14Cl3N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Resmetirom Impurity 40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H14Cl3N3O2 |
| Molecular Weight | 374.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom impurity 104 (CAS CATO-C4X-2912104)
- Resmetirom Impurity 12 (CAS CATO-C4X-291212)
- Resmetirom Impurity 61 (CAS CATO-C4X-291261)
- Resmetirom impurity 129 (CAS CATO-C4X-2912129)
- Resmetirom Impurity 126 (CAS CATO-C4X-2912126)
- Resmetirom impurity 71 (CAS CATO-C4X-291271)
- Resmetirom impurity 95 (CAS CATO-C4X-291295)
- Resmetirom impurity 114 (CAS CATO-C4X-2912114)
Recommended Standards
- Isopropyl 5-chloro-1-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxylate (CAS 242471-96-1)
- (2R,3S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-3,4-dihydro-2H-pyran-3-ol (CAS 111902-03-5)
- 4-(3-Chloro-4-fluoro-phenyl)-5-(2,4-dichloro-phenyl)-4H-[1,2,4]triazole-3-thiol (CAS 380346-00-9)
- 6-Bromo-2-(3,4-dimethylphenyl)quinoline-4-carbonyl chloride (CAS 1160253-17-7)
- Melphalan EP Impurity K (CAS 109-89-7)
- Sertraline Impurity 21 (CAS 79617-89-3)
- Pazopanib Impurity 36 (CAS CATO-C4X-172536)
- 3-Amino-4H-chromen-4-one (CAS 59507-94-7)
- 2,6-dimethyl-1$l^{4},4-thiomorpholin-1-one hydrochloride (CAS 1803594-06-0)
- 2-(4'-(Hexyloxy)-[1,1'-biphenyl]-4-yl)pyrimidin-5-ol (CAS 143414-48-6)
- Ethyl (R)-5-(difluoromethyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxylate (CAS 2413410-02-1)
- Ethyl 2-isothiocyanato-5-methyl-4-phenylthiophene-3-carboxylate (CAS 861239-52-3)
- 1-(Pyrrolidin-3-yl)urea hydrochloride (CAS 1423032-78-3)
- Amyloid Precursor Frameshift Mutant C-Terminal Peptide trifluoroacetate salt (CAS 189125-14-2)
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