Resmetirom impurity 129 CAS CATO-C4X-2912129
| CAS No. | CATO-C4X-2912129 |
| Molecular Formula | C15H13Cl2N5O2 |
| Molecular Weight | 366.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 366.20 g/mol gives Resmetirom impurity 129 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Resmetirom impurity 129 (CAS CATO-C4X-2912129), a pharmacopoeial impurity reference standard (molecular formula C15H13Cl2N5O2, MW 366.20 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Resmetirom impurity 129 (C15H13Cl2N5O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Resmetirom impurity 129 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H13Cl2N5O2 |
| Molecular Weight | 366.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Resmetirom Standards
- Resmetirom Impurity 61 (CAS CATO-C4X-291261)
- Resmetirom impurity 71 (CAS CATO-C4X-291271)
- Resmetirom impurity 95 (CAS CATO-C4X-291295)
- Resmetirom Impurity 40 (CAS 2947651-03-6)
- Resmetirom impurity 104 (CAS CATO-C4X-2912104)
- Resmetirom Impurity 36 (CAS CATO-C4X-291236)
- Resmetirom Impurity 12 (CAS CATO-C4X-291212)
- Resmetirom impurity 72 (CAS 1581304-51-9)
Recommended Standards
- Opicapone impurity 20 (CAS 2824922-36-1)
- Methyl 6-bromo-3-(3-phenoxypropoxy)picolinate (CAS 1135872-25-1)
- Olodaterol Impurity 10 (CAS CATO-C4X-194310)
- Diethyl 7-bromo-8-methylquinoline-2,3-dicarboxylate (CAS 1189106-88-4)
- Velpatasvir Impurity 2 (CAS 1378391-45-7)
- Selexipag Impurity 26 (CAS CATO-C4X-196126)
- Mezlocillin Impurity 5 (CAS CATO-C4X-18315)
- 3-Propyl-1-octanol (CAS 38514-12-4)
- Methyl 3,4-dichloro-5-nitrobenzoate (CAS 63105-53-3)
- 7-Oxabicyclo[2.2.1]hept-5-ene-2-carboxylic Acid (CAS 24363-23-3)
- N-(4-Methylphenyl)-4H-3,1-benzothiazin-2-amine (CAS 109768-67-4)
- 3-Indoxylphosphate,p-toluidinesalt (CAS 31699-61-3)
- (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one (CAS 1038924-65-0)
- Des-Ala28-Tirzepatide (CAS CATO-CPTD788945)
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