Cetirizine EP Impurity A CAS 303-26-4
| CAS No. | 303-26-4 |
| Molecular Formula | C17H19ClN2 |
| Molecular Weight | 286.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Cetirizine EP Impurity A (CAS 303-26-4), a pharmacopoeial impurity reference standard (molecular formula C17H19ClN2, MW 286.80 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Cetirizine EP Impurity A (C17H19ClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures Cetirizine EP Impurity A under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H19ClN2 |
| Molecular Weight | 286.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cetirizine Standards
- Cetirizine impurity N1 (CAS 58023-19-1)
- Cetirizine Impurity 22 (CAS 13391-38-3)
- Cetirizine Impurity Y (CAS 34605-45-3)
- Cetirizine Impurity 35 (CAS CATO-C4X-158235)
- Cetirizine Impurity 36 (CAS CATO-C4X-158236)
- Cetirizine EP Impurity G (CAS 109806-71-5)
- Cetirizine Impurity 26 (CAS CATO-C4X-158226)
- Cetirizine Impurity C18 (CAS 13391-39-4)
Recommended Standards
- Levocetirizine Impurity 1 (Chlorobenzhydryl piperazine) (CAS 300543-56-0)
- Levocetirizine Impurity 66 (CAS 439858-21-6)
- tert-Butyl 2-(3-chloropropyl)-2-cyanopiperidine-1-carboxylate (CAS 960294-17-1)
- 3-Bromo-2-fluoro-6-(trifluoromethyl)phenylboronic acid (CAS 1451392-89-4)
- Bisoprolol Impurity 78 (CAS 2226263-67-6)
- Cefepime EP Impurity E(HCl) (CAS 103121-85-3)
- Linagliptin Impurity 61 HCl (CAS CATO-C4X-110161)
- 1-Chloro-4-ethoxy-2,5-difluorobenzene (CAS 1805225-21-1)
- 2-Bromo-3-methylnaphthalene-1,4-dione (CAS 3129-39-3)
- 2-((2-(3,4-Dichlorobenzylidene)-3-oxo-2,3-dihydrobenzofuran-6-yl)oxy)acetic acid (CAS 900894-52-2)
- Atropine Impurity 59 (CAS 2659259-66-0)
- 4-(Chloromethyl)piperidine Hydrochloride (CAS 1822-61-3)
- N'-hydroxy-4-[(methylsulfonyl)amino]benzenecarboximidamide (CAS 148459-01-2)
- Insulin Degludec Impurity 26 (CAS CATO-C4X-215726)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com