Citric Acid impurity 8 CAS 30306-93-5
| CAS No. | 30306-93-5 |
| Molecular Formula | C8H12O7 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Citric Acid impurity 8 (CAS 30306-93-5) is a certified pharmaceutical impurity reference standard with the molecular formula C8H12O7C7H10O7 and a molecular weight of 426.33 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Citric Acid impurity 8 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 426.33 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H12O7 C7H10O7 |
| Molecular Weight | 426.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
Related Citric Standards
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- Citric acid isopropyl ester, mixture (CAS 39413-05-3)
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Recommended Standards
- Nicardipine Impurity 49 (CAS CATO-C4X-171049)
- Chlorphenamine EP Impurity C(Maleate) (CAS 22630-25-7)
- Baricitinib Impurity 78 (CAS 2055723-11-8)
- 2-Bromo-4-(tert-butyl)-1-chlorobenzene (CAS 61024-95-1)
- Methyl 2-amino-6-chloroquinoline-3-carboxylate (CAS 1966890-94-7)
- 4-Bromo-3-methoxybenzenethiol (CAS 90150-98-4)
- 1-(4-Methylbenzoyl)piperidine-2-carboxylic acid (CAS 681827-45-2)
- 2-Bromo-4-(tert-butyl)-5-cyclopropoxypyridine (CAS 1243444-92-9)
- (1-(4-Iodobenzyl)piperidin-4-yl)methanol (CAS 1347310-81-9)
- Semaglutide impurity 244(Fmoc-His(Fmoc)-Aib-OH) (CAS CATO-C4X-2226244)
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