Chlorphenamine EP Impurity C(Maleate) CAS 22630-25-7
| CAS No. | 22630-25-7 |
| Molecular Formula | C15H17ClN2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Chlorphenamine EP Impurity C(Maleate) (CAS 22630-25-7) is a certified pharmaceutical impurity reference standard with the molecular formula C15H17ClN2C4H4O4 and a molecular weight of 376.84 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Chlorphenamine EP Impurity C(Maleate) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 376.84 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Chlorphenamine EP Impurity C(Maleate) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H17ClN2 C4H4O4 |
| Molecular Weight | 376.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorphenamine Standards
- Chlorphenamine Impurity 60 (CAS 1081516-68-8)
- Chlorphenamine EP Impurity B (CAS 1202-34-2)
- Chlorphenamine Impurity 8 (CAS 120244-82-8（free base）)
- Chlorphenamine Impurity 25 (CAS 122376-68-5)
- Chlorphenamine impurity 58 (CAS 123517-65-7)
- Chlorphenamine EP Impurity A (CAS 1246816-57-8)
- Chlorphenamine Impurity 61Maleic Acid (CAS 19428-44-5（free base）)
- Chlorphenamine Impurity 6 (CAS 20101-92-2)
Recommended Standards
- Nefopam Impurity 37 (CAS CATO-C4X-283737)
- Clobetasone butyrate EP Impurity C (CAS 639817-49-5)
- Muricholic Acid Impurity 22 (CAS 111824-32-9)
- Methyl 3-(5-cyclopropyl-3-(trifluoromethyl)-1h-pyrazol-1-yl)propanoate (CAS 1002033-74-0)
- 4-Nitro-1-[(4-nitrophenyl)methyl]-1h-pyrazole (CAS 90920-49-3)
- 7-Bromochromane-4-carboxylic acid (CAS 1620075-07-1)
- 5-Chloro-6-methoxyquinolin-8-amine (CAS 5396-19-0)
- (3S,4R)-1-Benzyl-4-(3-fluorophenyl)pyrrolidine-3-carboxylic acid (CAS 1395080-79-1)
- 3-Bromo-5-(2-fluoropropan-2-yl)pyridine (CAS 2090369-99-4)
- [α-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226159)
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