Ethyl 2-{[2-(3-chlorophenyl)-6-nitro-1H-1,3-benzimidazol-1-yl]oxy}propanoate CAS 303149-66-8
| CAS No. | 303149-66-8 |
| Molecular Formula | C18H16ClN3O5 |
| Molecular Weight | 389.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 2-{[2-(3-chlorophenyl)-6-nitro-1H-1,3-benzimidazol-1-yl]oxy}propanoate.
Ethyl 2-{[2-(3-chlorophenyl)-6-nitro-1H-1,3-benzimidazol-1-yl]oxy}propanoate (CAS 303149-66-8) is a high-purity analytical reference standard with the molecular formula C18H16ClN3O5 and a molecular weight of 389.79 g/mol.
Structurally, Ethyl 2-{[2-(3-chlorophenyl)-6-nitro-1H-1,3-benzimidazol-1-yl]oxy}propanoate (C18H16ClN3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 389.79 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 2-{[2-(3-chlorophenyl)-6-nitro-1H-1,3-benzimidazol-1-yl]oxy}propanoate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H16ClN3O5 |
| Molecular Weight | 389.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Ethyl Standards
- Ethyl 2-((2-(4-chlorophenyl)-6-nitro-1H-benzo[d]imidazol-1-yl)oxy)propanoate (CAS 282523-41-5)
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- 2-((1-(4-Chlorophenyl)-3-(methoxycarbonyl)-6-oxo-1,6-dihydropyridazin-4-yl)thio)pyridine 1-oxide (CAS 338756-25-5)
- 3-(2-Chlorophenyl)-5-[(E)-2-{[4-(trifluoromethyl)phenyl]amino}ethenyl]-1,2-oxazole-4-carbonitrile (CAS 320424-90-6)
- 1-[(4-Chlorophenyl)sulfanyl]-4-[(4-fluorophenoxy)methyl]-2-nitrobenzene (CAS 477869-49-1)
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Recommended Standards
- Phenyl (2-chloro-6,7,8-trimethoxyquinazolin-4-yl)carbamate (CAS 65962-96-1)
- 4-Chloro-N-(9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (CAS 90335-43-6)
- O-tert-Butyl-2-hydroxy Efavirenz (CAS 201218-08-8)
- 2-Chloro-5-((6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl)amino)cyclohexa-2,5-diene-1,4-dione (CAS 870959-62-9)
- Butriptyline - API Standards (CAS 35941-65-2)
- Ethyl (1S,2R)-2-benzylcyclopropane-1-carboxylate (CAS 1680198-25-7)
- 2-Bromo-3,6-dimethoxybenzaldehyde, 97% (CAS 85432-87-7)
- tert-Butyl 5-(ethoxy(hydroxy)methyl)-3,3-difluoropiperidine-1-carboxylate (CAS 1379811-97-8)
- Diethyl Malonyldicarbamate (CAS 49754-15-6)
- Ytterbium(III) oxide (CAS 1314-37-0)
- tert-Butyl 4-Aminobenzoate (CAS 18144-47-3)
- 1-((Isopropylthio)methyl)-1H-benzo[d][1,2,3]triazole (CAS 302931-68-6)
- 2-(4-Chloro-8-iodo-7-methylpyrazolo[1,5-a][1,3,5]triazin-2-yl)propan-2-ol (CAS 2387601-68-3)
- Semaglutide Impurity 75 (CAS CATO-C4X-2226175)
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