2-(4-(Tert-butyl)phenoxy)-N-(4-chlorophenyl)-2,2-difluoroacetamide CAS 303151-28-2
| CAS No. | 303151-28-2 |
| Molecular Formula | C18H18ClF2NO2 |
| Molecular Weight | 353.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(4-(Tert-butyl)phenoxy)-N-(4-chlorophenyl)-2,2-difluoroacetamide.
CATO supplies 2-(4-(Tert-butyl)phenoxy)-N-(4-chlorophenyl)-2,2-difluoroacetamide (CAS 303151-28-2), a certified reference material (molecular formula C18H18ClF2NO2, MW 353.79 g/mol) for analytical method development and quality control.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 2-(4-(Tert-butyl)phenoxy)-N-(4-chlorophenyl)-2,2-difluoroacetamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 353.79 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18ClF2NO2 |
| Molecular Weight | 353.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 2-((4-Chlorophenyl)thio)-8-methyl-4-(trifluoromethyl)quinoline (CAS 338415-69-3)
- 6-Chloro-4-methyl-2-{[3-(trifluoromethyl)phenyl]sulfanyl}quinoline (CAS 478043-57-1)
- Dotinurad Impurity 89 (CAS CATO-C4X-249489)
- 2-(3-(4-Chloro-5-methyl-3-nitro-1h-pyrazol-1-yl)adamantan-1-yl)acetic acid (CAS 1004951-68-1)
- Pyridine, 2,2′-[(4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl]bis[6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)- (CAS 950596-41-5)
- 1-(Ethylsulfonyl)piperidin-4-amine hydrochloride (CAS 651056-79-0)
- 1,4-diaminocyclohexane-1-carboxylic acid dihydrochloride (CAS 1423032-43-2)
- 4-(2,4-Dimethoxyphenyl)phenol (CAS 1119454-89-5)
- 2-Amino-3-bromo-5-cyanobenzoic acid (CAS 2386000-89-9)
- Fmoc-D-HomoPhe(4-OCF3)-OH (CAS 1260614-07-0)
- 3-Cyclopropoxy-5-iodo-2-isopropoxypyridine (CAS 1243399-11-2)
- Ursodeoxycholic Acid EP Impurity H (CAS 78919-26-3)
- Evocalcet Impurity 22 (CAS CATO-C4X-248522)
- Semaglutide impurity 247 (CAS CATO-C4X-2226247)
Why CATO?
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