Vandetanib N-Hydroxymethyl Analog CAS 910298-61-2
| CAS No. | 910298-61-2 |
| Molecular Formula | C22H24BrFN4O3 |
| Molecular Weight | 491.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Vandetanib N-Hydroxymethyl Analog (CAS 910298-61-2), molecular formula C22H24BrFN4O3 and molecular weight 491.35 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, Vandetanib N-Hydroxymethyl Analog is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 491.35 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H24BrFN4O3 |
| Molecular Weight | 491.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 4 |
Related Vandetanib Standards
Recommended Standards
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- 2-Amino-3-(quinolin-3-yl)propanoic acid (CAS 26988-99-8)
- Methyl 4-{[(tert-Butoxy)carbonyl]amino}-2-methyl-1h-pyrrole-3-carboxylate (CAS 1432678-96-0)
- N-(5-Bromo-2-fluorophenyl)-N-methyl-DL-glycine Methyl Ester (CAS 1896795-14-4)
- 4,6-Dichloro-5-(difluoromethyl)pyridine-3-sulfonamide (CAS 1806833-33-9)
- (E)-1-(4,5-dibromothiophen-2-yl)-3-(dimethylamino)prop-2-en-1-one (CAS 900019-43-4)
- Ethyl 5-amino-1-(4-bromophenyl)-1H-pyrazole-3-carboxylate (CAS 1264042-04-7)
- Hexapeptide-10 (CAS 146439-94-3)
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