8-Chloro-5-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one CAS 303986-21-2
| CAS No. | 303986-21-2 |
| Molecular Formula | C17H11Cl2F3N6O |
| Molecular Weight | 443.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 8-Chloro-5-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
8-Chloro-5-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one (CAS 303986-21-2) is a high-purity analytical reference standard with the molecular formula C17H11Cl2F3N6O and a molecular weight of 443.21 g/mol.
The molecular framework of 8-Chloro-5-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one (C17H11Cl2F3N6O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C17H11Cl2F3N6O |
| Molecular Weight | 443.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Chloro Standards
- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(4-chlorobenzoyl)-1H-pyrrole-2-carbohydrazide (CAS 338403-47-7)
- (E)-(1-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methyl-1H-imidazol-4-yl}ethylidene)[(4-chlorophenyl)methoxy]amine (CAS 303150-51-8)
- 4-Chloro-N-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}phenyl)benzamide (CAS 338407-33-3)
- 1-[(2-Chloro-6-fluorophenyl)methyl]-4-(4-chlorobenzoyl)-3-methyl-1,2,3,4-tetrahydroquinoxalin-2-one (CAS 317822-31-4)
- 1-(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(3-chlorobenzyl)piperidine-4-carboxamide (CAS 439108-55-1)
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Recommended Standards
- 5-(4-Bromobenzoyl)-4-hydroxy-6-phenyl-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one (CAS 624725-94-6)
- Opicapone Impurity 73 (CAS CATO-C4X-240473)
- 2-Iodo-6-methyl-5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1227268-96-3)
- Guanosine 5'-Diphosphate (CAS 146-91-8)
- 3-(4-Methoxyphenyl)prop-2-en-1-amine (CAS 20850-13-9)
- 2-(2,5-Dimethylbenzoyl)-6-methoxypyridine (CAS 1187168-42-8)
- (E)-Hept-5-enoic acid (CAS 18776-90-4)
- ((2,4,6-Triisopropylphenyl)sulfonyl)-L-serine (CAS 159155-05-2)
- ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen sulfate (CAS 13435-43-3)
- 3,5-Dichloro-1-isobutylpyrazin-2(1H)-one (CAS 1437385-36-8)
- Ethyl 4-fluoro-2-methylphenylacetate (CAS 1208864-94-1)
- 1-Isobutyl-4-methyl-1H-imidazole (CAS 449174-33-8)
- 2-(Prop-2-yn-1-yl)-1H-benzo[d]imidazole (CAS 892639-25-7)
- Fas C- Terminal Tripeptide (CAS 189109-90-8)
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