2,6-Difluoro-N'-methyl-N'-(4-methyl-3-(methylsulfonyl)-6-phenylpyridin-2-yl)benzohydrazide CAS 303986-75-6
| CAS No. | 303986-75-6 |
| Molecular Formula | C21H19F2N3O3S |
| Molecular Weight | 431.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,6-Difluoro-N'-methyl-N'-(4-methyl-3-(methylsulfonyl)-6-phenylpyridin-2-yl)benzohydrazide.
2,6-Difluoro-N'-methyl-N'-(4-methyl-3-(methylsulfonyl)-6-phenylpyridin-2-yl)benzohydrazide (CAS 303986-75-6), molecular formula C21H19F2N3O3S and molecular weight 431.46 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2,6-Difluoro-N'-methyl-N'-(4-methyl-3-(methylsulfonyl)-6-phenylpyridin-2-yl)benzohydrazide (C21H19F2N3O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H19F2N3O3S |
| Molecular Weight | 431.46 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Difluoro Standards
- 2,5-Difluoro-9H-fluoren-9-one (CAS 2969-61-1)
- 2,2-Difluoro-2-(1,1,2,2-tetrafluoro-2-(perfluorobutoxy)ethoxy)ethan-1-ol (CAS 152914-73-3)
- 1,3-Difluoro-2-(2-fluoro-5-iodo-4-methylphenoxy)-5-(trifluoromethyl)benzene (CAS 2244084-27-1)
- 1,3-Difluoro-2-(4-fluoro-5-iodo-2-methylphenoxy)-5-(trifluoromethyl)benzene (CAS 2244086-98-2)
- 2-((2,4-Difluoro-N-(4-methoxyphenyl)phenyl)sulfonamido)-N-phenylacetamide (CAS 852917-90-9)
- (2R)-1,1-difluoro-2-palmitoyloxy-3-phosphopropane (CAS 474329-47-0)
- 4-(Difluoro(3,4,5-trifluorophenoxy)methyl)-4'-pentyl-1,1'-bi(cyclohexane) (CAS 208338-52-7)
- 5,7-Difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indole (CAS 1878207-49-8)
Recommended Standards
- (S)-8-(4-(((S)-2-Aminopropanoyl)oxy)piperidin-1-yl)-9-fluoro-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic acid (CAS 706809-20-3)
- 2-Fluoro-n-{2-[5-({[(2-fluorophenyl)carbamoyl]methyl}sulfanyl)-4-methyl-4h-1,2,4-triazol-3-yl]ethyl}benzamide (CAS 767326-29-4)
- (R)-6-(2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo-[1,5-a]pyrimidin-3-yl)-2-o-tolylpyridazin-3(2H)-one (CAS 928344-12-1)
- 5-Nitro-N'-[(1E)-[7-(prop-2-en-1-yloxy)naphthalen-1-yl]methylidene]-1-benzothiophene-2-carbohydrazide (CAS 866142-49-6)
- 3-Iodopyridine-2,5-diamine (CAS 1125410-09-4)
- 4-Acetamido-2-hydroxy-5-methylaniline (CAS 2055118-99-3)
- 2-fluoro-4-(trifluoromethyl)benzamide (CAS 207853-64-3)
- N-(benzo[d][1,3]dioxol-5-yl)-1-(4-isopropylphenyl)methanimine (CAS 74760-63-7)
- 2-(2,5-Dichlorophenyl)pyrimidine-5-carboxaldehyde (CAS 1361825-61-7)
- URB 937 (CAS 1357160-72-5)
- 4-[(2,2,2-trifluoroethyl)sulfamoyl]benzene-1-sulfonyl chloride (CAS 1036475-80-5)
- N-(2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pivalamide (CAS 2246741-86-4)
- 1-(Quinazolin-6-yl)ethanone (CAS 851444-87-6)
- Peptide 432 (CAS CATO-CPTD788432)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com