Methyl 3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-4-isoxazolecarboxylate CAS 303997-60-6
| CAS No. | 303997-60-6 |
| Molecular Formula | C12H8ClF3N2O3 |
| Molecular Weight | 320.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Methyl 3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-4-isoxazolecarboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Methyl 3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-4-isoxazolecarboxylate (CAS 303997-60-6) is a high-purity analytical reference standard with the molecular formula C12H8ClF3N2O3 and a molecular weight of 320.65 g/mol.
Methyl 3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-4-isoxazolecarboxylate (C12H8ClF3N2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H8ClF3N2O3 |
| Molecular Weight | 320.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 5-(3-Chlorophenoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (CAS 282523-49-3)
- 3-(4-Bromo-2-chlorophenoxy)-N,N-diethylpropan-1-amine (CAS 1704095-78-2)
- Ethyl 1-(6-chloropyridazin-3-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 1156803-06-3)
- N-[(3-bromoadamantan-1-yl)methyl]-2-chloroacetamide (CAS 1423026-65-6)
- 1,5-Bis(2,3-Epoxypropoxy)-2,2,3,3,4,4-Hexafluoropentane (CAS 4798-39-4)
- 2-{1-[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]ethyl}-2,3-dihydro-1H-isoindole-1,3-dione (CAS 1795518-55-6)
- 2-(1-(Cyclopropylmethyl)-7-oxo-1H-pyrrolo[2,3-c]pyridin-6(7H)-yl)acetic acid (CAS 1708013-62-0)
- 1-((4-Bromophenyl)sulfonyl)-2-((2-chlorobenzyl)thio)-4,5-dihydro-1H-imidazole (CAS 868217-81-6)
- 2,3-Dimethyl-3-(2-thiomethylphenyl)propiophenone (CAS 898754-72-8)
- 2-[5-(oxan-4-yl)-1,3,4-oxadiazol-2-yl]piperidine hydrochloride (CAS 1803567-39-6)
- tert-Butyl 4-((3-cyanophenyl)sulfonyl)piperidine-1-carboxylate (CAS 887589-99-3)
- 3-Hydroxy-5-pentylcyclohex-2-en-1-one (CAS 58016-29-8)
- Ethyl 2-amino-3-(1h-pyrazol-1-yl)propanoate (CAS 803635-32-7)
- Semaglutide impurity 289 (CAS CATO-C4X-2226289)
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