Chlorambucil CAS 305-03-3
| CAS No. | 305-03-3 |
| Molecular Formula | C14H19Cl2NO2 |
| Molecular Weight | 304.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Chlorambucil is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Chlorambucil (CAS 305-03-3), molecular formula C14H19Cl2NO2 and molecular weight 304.21 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Chlorambucil (C14H19Cl2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 304.21 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H19Cl2NO2 |
| Molecular Weight | 304.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorambucil Standards
- Meta-Chlorambucil (CAS 134862-11-6)
- Chlorambucil EP Impurity G (CAS 178481-89-5)
- Chlorambucil Impurity 2 (CAS 94086-78-9)
- Chlorambucil EP Impurity A (CAS 27171-89-7)
- Chlorambucil ethyl ester (CAS 64977-24-8)
- Chlorambucil EP Impurity B (CAS 116505-53-4)
- Chlorambucil EP Impurity D (CAS 94236-91-6)
- Chlorambucil Sodium Salt (CAS 1030-06-4)
Recommended Standards
- Bis(2-nitrophenyl) Carbonate (CAS 81420-42-0)
- Naphthalene-2,3,6,7-tetracarboxylic acid (CAS 42200-15-7)
- 2-Bromo-N-(2-(pyrrolidin-1-yl)ethyl)thiazole-4-carboxamide (CAS 867333-36-6)
- 3,5-Dinitro-4-phenoxybenzoic acid (CAS 35138-18-2)
- Sodium maleate dihydrate (CAS 53172-74-0)
- 7-Bromo-2,3-dihydrobenzo[b]thiepin-4(5H)-one (CAS 1956324-61-0)
- 4,6-Dimethyl-2-(pyrrolidin-3-ylthio)pyrimidine (CAS 1250902-32-9)
- 1-(4-Chlorophenyl)cyclobutanecarbonyl chloride (CAS 89421-95-4)
- 5,7-Dibromo-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (CAS 130064-06-1)
- 2-(Aminomethyl)-6-(difluoromethyl)-3-fluoro-5-hydroxypyridine (CAS 1807133-09-0)
- Bifonazole EP Impurity C(Clotrimazole EP Impurity D) (CAS 288-32-4)
- 6,6-Dimethyl-3-azabicyclo[3.1.0]Hexane-2-carboxylic acid (CAS 1822435-58-4)
- 1-[4-(Trifluoromethyl)-2-pyridyl]piperidine-4-carboxylic Acid (CAS 1256792-04-7)
- Glucagon-like peptide 2 (CAS 89750-15-2)
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