3-Chloro-5-(2-chlorophenyl)isothiazole-4-carboxylic acid CAS 306935-52-4
| CAS No. | 306935-52-4 |
| Molecular Formula | C10H5Cl2NO2S |
| Molecular Weight | 274.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Chloro-5-(2-chlorophenyl)isothiazole-4-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-Chloro-5-(2-chlorophenyl)isothiazole-4-carboxylic acid (CAS 306935-52-4) is a high-purity analytical reference standard with the molecular formula C10H5Cl2NO2S and a molecular weight of 274.12 g/mol.
3-Chloro-5-(2-chlorophenyl)isothiazole-4-carboxylic acid (C10H5Cl2NO2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-Chloro-5-(2-chlorophenyl)isothiazole-4-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H5Cl2NO2S |
| Molecular Weight | 274.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 3-Bromo-5-phenyl-1H-pyrazolo[3,4-b]pyridine (CAS 537678-51-6)
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- 3-Bromo-2-phenylimidazo[1,2-b]pyridazine (CAS 802580-12-7)
- 4-(2,4-Dichlorophenyl)thiazole-2-carboxylic Acid (CAS 952959-45-4)
- 4-(1-Phenyl-1H-pyrazol-4-yl)piperidine (CAS 1225514-12-4)
- 3-(Chloromethyl)-5-(difluoromethyl)pyridine hydrobromide (CAS 1646288-39-2)
- 1-benzyl-3,3-dimethylthiourea hydroiodide (CAS 1221722-46-8)
- 2-(2-Ethyl-1H-benzo[d]imidazol-1-yl)ethan-1-ol (CAS 51215-27-1)
- 1-(3-Methyl-2,3-dihydro-1-benzofuran-2-yl)ethan-1-amine hydrochloride (CAS 1376054-09-9)
- 4-(3-Chloro-5-methoxyphenyl)piperidine hydrochloride (CAS 2168546-86-7)
- 6-Ethyl-2-methylquinoline-4-carboxylic acid (CAS 590376-60-6)
- Methyl 2-(6-ethyl-4-oxoquinolin-1(4H)-yl)propanoate (CAS 1279201-32-9)
- Ceftiofur Impurity 3 (CAS 120882-20-4)
- Characteristic MSH-Tetrapeptide (CAS 4289-02-5)
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