2-(2-Chloro-4-fluorophenyl)acetamide CAS 306937-35-9
| CAS No. | 306937-35-9 |
| Molecular Formula | C8H7ClFNO |
| Molecular Weight | 187.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(2-Chloro-4-fluorophenyl)acetamide.
CATO supplies 2-(2-Chloro-4-fluorophenyl)acetamide (CAS 306937-35-9), a certified reference material (molecular formula C8H7ClFNO, MW 187.60 g/mol) for analytical method development and quality control.
Structurally, 2-(2-Chloro-4-fluorophenyl)acetamide (C8H7ClFNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 187.60 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7ClFNO |
| Molecular Weight | 187.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
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- 5-Chloro-3-cyclopropoxy-2-fluoropyridine (CAS 1243363-55-4)
- 2-Chloro-5-cyclopropoxy-4-fluoropyridine (CAS 1243375-83-8)
- 4-Chloro-3-cyclopropoxy-5-fluoropyridine (CAS 1243399-10-1)
- 3-Chloro-5-cyclopropoxy-2-fluoropyridine (CAS 1243404-92-3)
- 5-Chloro-4-cyclopropoxy-2-fluoropyridine (CAS 1243423-05-3)
Recommended Standards
- 1-(4-Amino-3-chloro-5-fluoro-phenyl)-ethanone (CAS 56339-99-2)
- 2-(2-Chloro-6-fluorophenyl)acetamide (CAS 895903-54-5)
- 1-(3-Chloro-4-fluorophenyl)guanidine (CAS 76635-22-8)
- 2’-Amino-5’-chloro-4’-fluoroacetophenone (CAS 937816-85-8)
- Tert-butyl ((2S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)(1-oxo-1,3-diphenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (CAS 2439090-56-7)
- 3-Amino-3-methyl-1-morpholinobutan-1-one hydrochloride (CAS 1415898-61-1)
- 3-Isobutyl-6-methylpiperazine-2,5-dione (CAS 1803-60-7)
- n-(1-Methoxypropan-2-yl)-1h-imidazole-1-carboxamide (CAS 1087788-32-6)
- 2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 285134-43-2)
- Triptorelin Impurity 20 ·x(Acetate salt) (CAS 303102-15-0)
- 2,4-Dichloro-5-(1,1-difluoroethyl)pyrimidine (CAS 2776191-13-8)
- 2-((2-Methoxybenzyl)amino)acetonitrile (CAS 63086-26-0)
- Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate (CAS 86477-10-3)
- (Met(O)2?)-Glucagon (1-29) (human, rat, porcine) (CAS 75217-63-9)
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