Betamethasone Valerate EP Impurity D CAS 3081732-65-9
| CAS No. | 3081732-65-9 |
| Molecular Formula | C27H37BrO6 |
| Molecular Weight | 537.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 537.48 g/mol gives Betamethasone Valerate EP Impurity D distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Betamethasone Valerate EP Impurity D (CAS 3081732-65-9, C27H37BrO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, bromine substitution, Betamethasone Valerate EP Impurity D is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 537.48 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Betamethasone Valerate EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H37BrO6 |
| Molecular Weight | 537.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | Br-containing |
Related Betamethasone Standards
- Betamethasone Impurity 110 (CAS CATO-C4X-1437110)
- Betamethasone impurity 58 (CAS CATO-C4X-143758)
- Betamethasone Impurity 115 (CAS 1564242-51-8)
- Betamethasone impurity 95 (CAS 1815577-58-2)
- Betamethasone Dipropionate EP Impurity E (CAS 5534-09-8)
- Betamethasone Valerate EP Impurity G (CAS CATO-C4X-143722)
- Betamethasone-17-butyrate-21-propionate (CAS 5534-02-1)
- Betamethasone-D10 Dipropionate (CAS 5593-20-4 (unlabelled))
Recommended Standards
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- Ciprofloxacin Impurity 40 (CAS CATO-C4X-136240)
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- 2-(Benzo[d]thiazol-2-yl)-4-chloro-3-oxobutanenitrile (CAS 160148-12-9)
- Benzyl (2S)-2-{[(3-chloro-2-pyrazinyl)methyl]carbamoyl}-1-pyrrolidinecarboxylate (CAS 1418307-17-1)
- 3-(4-Methylpyridin-3-yl)azetidin-3-ol (CAS 1516169-41-7)
- 2,4,6-Tribromobenzene-1,3-diamine (CAS 62477-06-9)
- tert-butyl N-(tert-butoxycarbonylamino)-N-[3-(4-fluorophenyl)-1-bicyclo[1.1.1]pentanyl]carbamate (CAS 2149634-52-4)
- Semaglutide impurity 107 (CAS CATO-C4X-2226107)
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