Betamethasone impurity 95 CAS 1815577-58-2
| CAS No. | 1815577-58-2 |
| Molecular Formula | C22H31FO11P2 |
| Molecular Weight | 552.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Betamethasone impurity 95 is closely related to a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Betamethasone impurity 95 (CAS 1815577-58-2) is a certified pharmaceutical impurity reference standard with the molecular formula C22H31FO11P2 and a molecular weight of 552.42 g/mol.
Structurally, Betamethasone impurity 95 (C22H31FO11P2) contains a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 552.42 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H31FO11P2 |
| Molecular Weight | 552.42 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone Valerate EP Impurity G (CAS CATO-C4X-143722)
- Betamethasone Dipropionate EP Impurity G (CAS 1186048-33-8)
- Betamethasone Impurity 110 (CAS CATO-C4X-1437110)
- Betamethasone Valerate EP Impurity D (CAS 3081732-65-9)
- Betamethasone β-D-Glucuronide (CAS 744161-79-3)
- Betamethasone impurity 58 (CAS CATO-C4X-143758)
- Betamethasone Impurity 115 (CAS 1564242-51-8)
- Betamethasone Dipropionate impurity 02 (CAS 1186048-34-9)
Recommended Standards
- (4-Oxo-3-{[3-(trifluoromethyl)benzoyloxy]methyl}-3,4-dihydro-2H-1-benzopyran-3-yl)methyl 3-(trifluoromethyl)benzoate (CAS 338755-81-0)
- ARQ-621 (CAS 1095253-39-6)
- Ethyl 4-(2-(4-((4-chloro-1-(3-chloro-4-methylphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)amino)phenyl)acetamido)benzoate (CAS 6857-78-9)
- Epitheaflagallin 3-O-gallate (CAS 102067-92-5)
- Drotaverin Impurity 70 (CAS CATO-C4X-243570)
- Celecoxib Impurity 45 (CAS 90824-33-2)
- Selumetinib Impurity 23 (CAS CATO-C4X-305323)
- 2-Amino-1-(1-cyclopropyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)ethanone (CAS 1774905-03-1)
- 6-methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid (CAS 1260383-27-4)
- (SP-4-2)-[1,1′-(1,2-Ethanediyl)bis[1,1-diphenylphosphine-κP]]diiodonickel (CAS 15629-91-1)
- 3-[(4-tert-butylphenyl)methylidene]-1h,2h,3h-cyclopenta[b]quinoline-9-carboxylic acid (CAS 647036-26-8)
- 1-(Furan-2-carbonyl)piperidine-3-carboxylic acid (CAS 436093-09-3)
- 1-(Trifluoromethoxy)-2-(((trifluoromethyl)sulfonyl)methyl)benzene (CAS 1346521-39-8)
- Hippocampal Cholinergic Neurostimulating Peptide (CAS 140158-49-2)
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