1-(Difluoromethyl)-2-(trifluoromethyl)benzene CAS 312-95-8
| CAS No. | 312-95-8 |
| Molecular Formula | C8H5F5 |
| Molecular Weight | 196.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(Difluoromethyl)-2-(trifluoromethyl)benzene is closely related to fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(Difluoromethyl)-2-(trifluoromethyl)benzene (CAS 312-95-8) is a high-purity analytical reference standard with the molecular formula C8H5F5 and a molecular weight of 196.12 g/mol.
The molecular framework of 1-(Difluoromethyl)-2-(trifluoromethyl)benzene (C8H5F5) is characterized by fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-(Difluoromethyl)-2-(trifluoromethyl)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5F5 |
| Molecular Weight | 196.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Difluoromethyl Standards
- 1-(Difluoromethyl)-3-(trifluoromethyl)benzene (CAS 1214358-15-2)
- 1-(Difluoromethyl)-4-(trifluoromethyl)benzene (CAS 2251-82-3)
- 2,6-Bis(difluoromethyl)-4H-pyran-4-one (CAS 847947-32-4)
- 4-(Difluoromethyl)-2,6-difluorobenzene-1,3-diol (CAS 2092183-23-6)
- 2-(Difluoromethyl)-4h-chromen-4-one (CAS 156909-07-8)
- 3-(Difluoromethyl)-6-formyl-5-methylpicolinonitrile (CAS 1804416-49-6)
- 3-(Difluoromethyl)-2-formyl-5-methylisonicotinonitrile (CAS 1804687-16-8)
- 3-(Difluoromethyl)-4-formyl-5-methylpicolinonitrile (CAS 1805022-39-2)
Recommended Standards
- A-trifluoroacetyl-d-valerolactone (CAS 183279-74-5)
- 3,4-Difluoro-5-methylbenzotrifluoride (CAS 1806370-13-7)
- 1-(Trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-4-carboxylic acid (CAS 2624134-57-0)
- 2,3-Difluoro-6-methylbenzotrifluoride (CAS 1806332-84-2)
- N-(4-bromophenyl)aminosulfonamide (CAS 556068-14-5)
- Methyl (r)-3-amino-3-(pyridin-2-yl)propanoate (CAS 1213041-75-8)
- n-((Tetrahydro-2h-pyran-4-yl)methyl)cyclobutanamine (CAS 1250031-65-2)
- N-Nitroso Diphenhydramine Impurity 12 (CAS CATO-C4X-142412)
- 2-Methyl-1-phenyl-1h-pyrrole-3-carbaldehyde (CAS 215718-05-1)
- 2,3,5,6,8,9,11,12-Octahydronaphtho[2,3-b][1,4,7,10,13]pentaoxacyclopentadecine (CAS 17454-47-6)
- 1-Phenyl-3-(1H-1,2,4-triazol-1-yl)propan-1-amine (CAS 883291-44-9)
- Bortezomib Impurity 12 Trifluoroacetic Acid (CAS 477254-69-6)
- 3-{[(4-fluorophenyl)methoxy]methyl}pyrrolidine (CAS 933716-70-2)
- Ephrin-A2-Selective YSA-Peptide (CAS 532441-10-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com