Bortezomib Impurity 12 Trifluoroacetic Acid CAS 477254-69-6
| CAS No. | 477254-69-6 |
| Molecular Formula | C15H28BNO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Bortezomib Impurity 12 Trifluoroacetic Acid (CAS 477254-69-6), a pharmacopoeial impurity reference standard (molecular formula C15H28BNO2C2HF3O2, MW 379.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, Bortezomib Impurity 12 Trifluoroacetic Acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 379.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H28BNO2 C2HF3O2 |
| Molecular Weight | 379.23 g/mol |
| Purity | >85% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.5 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Bortezomib Standards
- Bortezomib Impurity 77 (CAS 103435-88-7)
- Bortezomib Impurity 36 (CAS 1093959-75-1)
- Bortezomib Impurity 35 (CAS 1104011-35-9)
- Bortezomib Impurity 45 (CAS 110755-29-8)
- Bortezomib Impurity 6 (CAS 1132709-14-8)
- Bortezomib Impurity 7 (CAS 1132709-15-9)
- Bortezomib Impurity 5 (CAS 1132709-16-0)
- Bortezomib Impurity 2 (CAS 114457-94-2)
Recommended Standards
- Emedastine impurity 36 (CAS CATO-C4X-226736)
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- Avatrombopag Impurity 102 (CAS CATO-C4X-2234102)
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- Dimethyl 2-benzylmalonate (CAS 65749-05-5)
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- Benzyl-isopropyl-(S)-1-pyrrolidin-2-ylmethyl-amine (CAS 1353973-78-0)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com