1-(Chloromethyl)pyrrolidin-2-one CAS 31282-95-8
| CAS No. | 31282-95-8 |
| Molecular Formula | C5H8ClNO |
| Molecular Weight | 133.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(Chloromethyl)pyrrolidin-2-one.
1-(Chloromethyl)pyrrolidin-2-one (CAS 31282-95-8), molecular formula C5H8ClNO and molecular weight 133.58 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 1-(Chloromethyl)pyrrolidin-2-one is typically white to off-white liquid. Its solid-state physicochemical attributes — including a molecular weight of 133.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(Chloromethyl)pyrrolidin-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H8ClNO |
| Molecular Weight | 133.58 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
- (R)-5-(Chloromethyl)pyrrolidin-2-one (CAS 138541-53-4)
- (S)-5-(Chloromethyl)pyrrolidin-2-one (CAS 72479-04-0)
- 5-(Chloromethyl)-3-methyl-4,5-dihydroisoxazole (CAS 69578-12-7)
- 53598-88-2 (+/-)-4-(Chloromethyl)-4-methylazetidin-2-one MFCD19232808 (CAS 53598-88-2)
- 3-(Chloromethyl)isothiazole (CAS 1246549-42-7)
- 5-(Chloromethyl)isothiazole (CAS 1710-68-5)
- 4-(Chloromethyl)isothiazole (CAS 89033-79-4)
- 5-(Chloromethyl)thiazole (CAS 45438-77-5)
Recommended Standards
- 1-(azetidin-1-yl)-2-chloroethan-1-one (CAS 63177-41-3)
- 3-Chloro-1-methyl-2-pyrrolidinone (CAS 208585-67-5)
- 4-chloro-1H-pyrrole-2-carbaldehyde (CAS 33515-58-1)
- (E)-5-Chloropent-4-enamide (CAS 88981-60-6)
- 3-Amino-6-chloro-2-pyrazinecarbonitrile (CAS 17231-50-4)
- 2-[2-(Methoxycarbonyl)phenyl]acetic Acid (CAS 14736-49-3)
- 5-(Hydroxymethyl)-4-(1H-imidazol-2-yl)-2-methylpyridin-3-ol (CAS 667398-46-1)
- (3-Methyl-1H-pyrazol-1-yl)methanol (CAS 98816-32-1)
- 2-(4-Aminophenyl)pyrimidine-5-carboxylic acid (CAS 1416438-17-9)
- 4-Chloro-5,6-diphenylthieno[2,3-d]pyrimidine (CAS 1208346-69-3)
- 1-(4-Cyclopropylphenyl)-2,2,2-trifluoroethan-1-one (CAS 2168894-56-0)
- (4-((2-Methoxyethyl)thio)phenyl)boronic acid (CAS 1032825-12-9)
- 3-Nitro-N-(p-tolyl)benzenesulfonamide (CAS 4284-46-2)
- Met(O)14-Exenatide trifluoroacetate salt (CAS 1678417-38-3)
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