4-(Chloromethyl)isothiazole CAS 89033-79-4
| CAS No. | 89033-79-4 |
| Molecular Formula | C4H4ClNS |
| Molecular Weight | 133.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(Chloromethyl)isothiazole (C4H4ClNS) is characterized by a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
4-(Chloromethyl)isothiazole (CAS 89033-79-4) is a high-purity analytical reference standard with the molecular formula C4H4ClNS and a molecular weight of 133.60 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-(Chloromethyl)isothiazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H4ClNS |
| Molecular Weight | 133.60 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloromethyl Standards
- 3-(Chloromethyl)isothiazole (CAS 1246549-42-7)
- 5-(Chloromethyl)isothiazole (CAS 1710-68-5)
- 5-(Chloromethyl)thiazole (CAS 45438-77-5)
- (R)-5-(Chloromethyl)pyrrolidin-2-one (CAS 138541-53-4)
- (S)-5-(Chloromethyl)pyrrolidin-2-one (CAS 72479-04-0)
- 1-(Chloromethyl)pyrrolidin-2-one (CAS 31282-95-8)
- 5-(Chloromethyl)-3-methyl-4,5-dihydroisoxazole (CAS 69578-12-7)
- 53598-88-2 (+/-)-4-(Chloromethyl)-4-methylazetidin-2-one MFCD19232808 (CAS 53598-88-2)
Recommended Standards
- 3-Chlorothiophen-2-amine (CAS 491879-26-6)
- 4-Chloro-3-methylisothiazole (CAS 930-43-8)
- 2-Chloro-5-methylthiazole (CAS 33342-65-3)
- 2-Chloro-4-methylthiazole (CAS 26847-01-8)
- (1,3-Dimethyl-1H-pyrazol-4-yl)(phenyl)methanone (CAS 94989-98-7)
- 6-Methoxy-2-(methylthio)-N-(piperidin-3-ylmethyl)pyrimidin-4-amine hydrochloride (CAS 1353958-11-8)
- N,N'-((1,4-diazepane-1,4-disulfonyl)bis(4,1-phenylene))diacetamide (CAS 547722-10-1)
- Dotinurad Impurity 194 (CAS 50910-60-6 (free base))
- Ethyl 4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 161374-07-8)
- Fmoc-D-Leu-Ser(psi(Me,Me)pro)-OH (CAS CATO-CPTD788891)
- 1-(2-(Thiophen-3-yl)ethyl)-1h-pyrazol-3-amine (CAS 1339517-73-5)
- 2-(3-Chloropyridin-2-yl)-2H-1,2,3-triazole-4-carboxylic acid (CAS 1431728-93-6)
- p-(1-Adamantyl)toluene (CAS 1459-55-8)
- Myelin Basic Protein (85-99) Peptide Antagonist (CAS 444305-16-2)
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