3-Chloro-5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid CAS 312922-10-4
| CAS No. | 312922-10-4 |
| Molecular Formula | C16H11ClF3N3O4 |
| Molecular Weight | 401.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Chloro-5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid.
3-Chloro-5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 312922-10-4), molecular formula C16H11ClF3N3O4 and molecular weight 401.72 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C16H11ClF3N3O4, 3-Chloro-5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 401.72 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H11ClF3N3O4 |
| Molecular Weight | 401.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(2,4-difluorophenyl)-1H-pyrrole-2-carboxamide (CAS 338956-55-1)
- (3-(2-Chloro-6-fluorophenyl)-5-methylisoxazol-4-yl)(5-(trifluoromethyl)-2,3-dihydro-1H-1,4-diazepin-1-yl)methanone (CAS 478078-87-4)
- 3-Chloro-2-(2-((5-nitropyridin-2-yl)thio)-1H-imidazol-1-yl)-5-(trifluoromethyl)pyridine (CAS 303988-46-7)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-phenyl-1H-pyrrole-2-sulfonamide (CAS 321433-63-0)
- 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethan-1-one (CAS 444151-88-6)
- 4-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-4,5-dihydro-1H-imidazol-1-yl)benzoic acid (CAS 321433-53-8)
- (S)-2-((4-Chloro-6-(naphthalen-1-ylamino)-1,3,5-triazin-2-yl)amino)pentanedioic acid (CAS 61955-62-2)
- 5-Chloro-N-(2-(dimethylamino)ethyl)-6-oxo-1-(3-(trifluoromethyl)benzyl)-1,6-dihydropyridine-3-carboxamide (CAS 338981-07-0)
Recommended Standards
- 3-(4-Chlorophenyl)-5-(2,4-dichlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole (CAS 329727-31-3)
- Rivaroxaban Impurity 65 (CAS 73311-47-4)
- 2-((4-Bromophenyl)thio)-6-(4-chlorophenyl)nicotinonitrile (CAS 252059-04-4)
- Ethyl 2-bromo-5-((4-chlorophenyl)(hydroxy)methyl)-1-isopropyl-1H-imidazole-4-carboxylate (CAS 1448869-68-8)
- 5-Fluoro-1,3-dimethyl-1H-pyrazole-4-carbonyl chloride (CAS 202476-26-4)
- Methyl 3-(4-fluorobenzamido)-4-methylthiophene-2-carboxylate (CAS 677706-82-0)
- 5-[(4-chloro-3-methylphenoxy)methyl]furan-2-carbaldehyde (CAS 438220-50-9)
- Benzyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate (CAS 934664-22-9)
- Ethyl 2-amino-5-ethyloxazole-4-carboxylate (CAS 2101425-38-9)
- Phenylephrine Impurity 10 (CAS 14665-75-9)
- 1-Oxo-1,2-dihydroisoquinoline-3-carbaldehyde (CAS 75596-30-4)
- 2,6-Dichloropyridine-4-thiol (CAS 33256-13-2)
- (3S,4R)-4-methylpiperidin-3-ol (CAS 737737-29-0)
- [14-31]-Semaglutide (CAS CATO-C4X-2226262)
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