1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-phenyl-1H-pyrrole-2-sulfonamide CAS 321433-63-0
| CAS No. | 321433-63-0 |
| Molecular Formula | C16H11ClF3N3O2S |
| Molecular Weight | 401.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-phenyl-1H-pyrrole-2-sulfonamide (CAS 321433-63-0) is a high-purity analytical reference standard with the molecular formula C16H11ClF3N3O2S and a molecular weight of 401.79 g/mol.
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-phenyl-1H-pyrrole-2-sulfonamide (C16H11ClF3N3O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C16H11ClF3N3O2S |
| Molecular Weight | 401.79 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Chloro Standards
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Recommended Standards
- Ethyl 1-(4-(4-chlorophenyl)thiazol-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 159885-63-9)
- 2-(4-Chlorophenyl)-4-(4-(trifluoromethyl)phenyl)thiomorpholine-3,5-dione 1-oxide (CAS 252058-94-9)
- 4-(chloromethyl)-N-{2-[2-nitro-4-(trifluoromethyl)anilino]ethyl}benzamide (CAS 303188-07-0)
- 1,2,5,6-Tetrabromohexane (CAS 58443-86-0)
- 4-(2,4-Dimethyl-1H-pyrrol-3-yl)-2-ethyl-6-methyl-2,5-dihydro-1,2,3-triazine (CAS 545369-21-9)
- 3-Acetyladamantane-1-carboxylic acid (CAS 91442-73-8)
- 4-Chloro-5-(difluoromethyl)-3-fluoropyridin-2-ol (CAS 1806861-54-0)
- 2-(Pyrimidin-4-yl)acetaldehyde (CAS 120455-87-0)
- 2-Oxo-2-(2-propionamidophenyl)acetic acid (CAS 352330-52-0)
- 2-(2-Bromobenzyl)morpholine (CAS 1368849-19-7)
- (R)-Benzyl 3-(2-chloro-N-methylacetamido)pyrrolidine-1-carboxylate (CAS 1354006-71-5)
- 1-Methyl-3-cyclohexene-1-methanol (CAS 50552-10-8)
- 3-Chloro-2,5-dimethylbenzoic acid (CAS 60772-69-2)
- Neuropeptide Y (porcine) trifluoroacetate salt (CAS 83589-17-7)
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