2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethan-1-one CAS 444151-88-6
| CAS No. | 444151-88-6 |
| Molecular Formula | C18H16ClF4N3O |
| Molecular Weight | 401.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 401.79 g/mol gives 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethan-1-one distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethan-1-one (CAS 444151-88-6), a certified reference material (molecular formula C18H16ClF4N3O, MW 401.79 g/mol) for analytical method development and quality control.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethan-1-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 401.79 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H16ClF4N3O |
| Molecular Weight | 401.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-phenyl-1H-pyrrole-2-sulfonamide (CAS 321433-63-0)
- 4-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-4,5-dihydro-1H-imidazol-1-yl)benzoic acid (CAS 321433-53-8)
- (S)-2-((4-Chloro-6-(naphthalen-1-ylamino)-1,3,5-triazin-2-yl)amino)pentanedioic acid (CAS 61955-62-2)
- 5-Chloro-N-(2-(dimethylamino)ethyl)-6-oxo-1-(3-(trifluoromethyl)benzyl)-1,6-dihydropyridine-3-carboxamide (CAS 338981-07-0)
- 5-Chloro-N-[2-(dimethylamino)ethyl]-2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide (CAS 338977-54-1)
- 3-[(5-chloro-2,4-dimethoxyphenyl)sulfamoyl]-4-methoxybenzoic acid (CAS 721893-22-7)
- 3-Chloro-2-(2-((5-nitropyridin-2-yl)thio)-1H-imidazol-1-yl)-5-(trifluoromethyl)pyridine (CAS 303988-46-7)
- (3-(2-Chloro-6-fluorophenyl)-5-methylisoxazol-4-yl)(5-(trifluoromethyl)-2,3-dihydro-1H-1,4-diazepin-1-yl)methanone (CAS 478078-87-4)
Recommended Standards
- 2-(4-Chlorophenyl)-4-(4-(trifluoromethyl)phenyl)thiomorpholine-3,5-dione 1-oxide (CAS 252058-94-9)
- 3-[(4-Chlorophenyl)sulfanyl]-1-[4-(trifluoromethoxy)phenyl]pyrrolidine-2,5-dione (CAS 306732-50-3)
- Ethyl 1-(4-(4-chlorophenyl)thiazol-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 159885-63-9)
- (3,4-Dimethoxyphenyl)methyl N-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)carbamate (CAS 477848-94-5)
- 6-ETHYNYLIMIDAZO[1,2-A]PYRAZINE (CAS 1372096-41-7)
- methyl 2-amino-4-(methoxymethyl)thiophene-3-carboxylate (CAS 349662-41-5)
- Thiazole-5-carbonyl chloride (CAS 41125-73-9)
- Luliconazole Impurity 11 (CAS CATO-C4X-285311)
- Allyl (3-chlorophenyl)carbamate (CAS 25070-79-5)
- 1H-Indole-1-carboxylic acid, 5-[[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]sulfonyl]-, 1,1-dimethylethyl ester 503045-76-9 L-1705 (CAS 503045-76-9)
- 6-Chlorobenzo[c][1,8]naphthyridine (CAS 1416438-36-2)
- 3-[1-(3-Fluoro-4-methoxybenzoyl)piperidin-4-yl]-4-[(4-methylphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775335-58-4)
- 4-Iodo-2-indolinone (CAS 179536-52-8)
- Semaglutide Impurity 13 (CAS CATO-C4X-222613)
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