Tiotropium Impurity 27 CAS 3140-93-0
| CAS No. | 3140-93-0 |
| Molecular Formula | C4H2Br2S |
| Molecular Weight | 241.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Tiotropium Impurity 27 (CAS 3140-93-0), a pharmacopoeial impurity reference standard (molecular formula C4H2Br2S, MW 241.93 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Tiotropium Impurity 27 (C4H2Br2S) contains sulfur-containing functionality, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 241.93 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H2Br2S |
| Molecular Weight | 241.93 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
| Sulfur Atoms | 1 |
Related Tiotropium Standards
- Tiotropium EP Impurity A (CAS 4746-63-8)
- Tiotropium Bromide EP Impurity E; (CAS 26447-85-8)
- Tiotropium impurity 44 (CAS 4408-82-6)
- Tiotropium impurity 46 (CAS 7688-76-8)
- Tiotropium Bromide Impurity 14 (CAS 61616-97-5)
- Tiotropium Bromide Impurity 23 (CAS 54725-48-3)
- Tiotropium Impurity 41 (CAS CATO-C4X-176441)
- Tiotropium EP Impurity F (CAS 704-38-1)
Recommended Standards
- 2,4-Dibromothiophene (CAS 3140-92-9)
- (Z)-1,4-Dibromo-2,3-Dimethylbut-2-Ene (CAS 100758-26-7)
- 2,5-Dibromothiophene (CAS 3141-27-3)
- 2,5-Dibromohex-3-ene (CAS 100937-48-2)
- Terbutaline impurity 123 (CAS CATO-C4X-1183123)
- Topiroxostat Impurity 65 (CAS CATO-C4X-105565)
- Doxorubicin Dimer Impurity 17 (CAS 59325-98-3)
- 2-Methoxyethyl 2-(1-butyl-2-oxoindolin-3-ylidene)-7-methyl-3-oxo-5-(thiophen-2-yl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate (CAS 618078-02-7)
- 2-((2-Methylthiazol-4-yl)methyl)pyrimidine-4-carboxylic acid (CAS 1342671-50-4)
- 2-((2-(Aminomethyl)phenyl)(methyl)amino)ethan-1-ol (CAS 643087-97-2)
- 5-benzyl-2-chloropyrimidine (CAS 859209-15-7)
- 2-Methyl-N-((3-methylthiophen-2-yl)methyl)propan-2-amine hydrochloride (CAS 1050479-95-2)
- 2-(Cyclobutanecarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid (CAS 1171514-17-2)
- Semaglutide impurity 88 (CAS CATO-C4X-222688)
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