Tiotropium EP Impurity A CAS 4746-63-8
| CAS No. | 4746-63-8 |
| Molecular Formula | C10H8O3S2 |
| Molecular Weight | 240.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tiotropium EP Impurity A.
CATO supplies Tiotropium EP Impurity A (CAS 4746-63-8), a pharmacopoeial impurity reference standard (molecular formula C10H8O3S2, MW 240.30 g/mol) used for the identification and quantification of trace impurities in APIs.
Tiotropium EP Impurity A (C10H8O3S2) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8O3S2 |
| Molecular Weight | 240.30 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Sulfur Atoms | 2 |
Related Tiotropium Standards
- Tiotropium Impurity 27 (CAS 3140-93-0)
- Tiotropium Bromide EP Impurity E; (CAS 26447-85-8)
- Tiotropium impurity 44 (CAS 4408-82-6)
- Tiotropium impurity 46 (CAS 7688-76-8)
- Tiotropium EP Impurity F (CAS 704-38-1)
- Tiotropium Bromide Impurity 14 (CAS 61616-97-5)
- Tiotropium Bromide Impurity 23 (CAS 54725-48-3)
- Tiotropium Impurity 41 (CAS CATO-C4X-176441)
Recommended Standards
- Perindopril EP Impurity J (CAS 685523-06-2)
- Misoprostol EP Impurity F (CAS 41138-61-8)
- Anastrozole Impurity 18 (CAS 120511-89-9)
- Acetylcysteine EP Impurity A (CAS 56-89-3)
- Altrenogest impurity 14 (CAS 165541-64-0)
- Picosulfate impurity 26 (CAS CATO-C4X-123726)
- Formoterol EP Impurity H (Enantiomer Mixture) (CAS CATO-C4X-15258)
- (2,4-Diamino-5,6,7,8-tetrahydropteridin-6-yl)methanol, trifluoroacetic acid (CAS 1955531-99-3)
- Nimbin (CAS 5945-86-8)
- 3-Amino-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one (CAS 1684425-51-1)
- 1-Chloro-4-(isopropylsulfonyl)butane (CAS 128147-28-4)
- N-((3-Bromoisoxazol-5-yl)methyl)-2-methoxyacetamide (CAS 1447962-11-9)
- 4-(4-Ethyl-5-((3-fluorobenzyl)thio)-4H-1,2,4-triazol-3-yl)pyridine (CAS 618426-81-6)
- TRAF6 Peptide trifluoroacetate salt (CAS 852805-92-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com