Tiotropium Bromide Impurity 23 CAS 54725-48-3
| CAS No. | 54725-48-3 |
| Molecular Formula | C17H21NO3 |
| Molecular Weight | 287.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tiotropium Bromide Impurity 23 (C17H21NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Tiotropium Bromide Impurity 23 (CAS 54725-48-3, C17H21NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H21NO3 |
| Molecular Weight | 287.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Nitrogen Atoms | 1 |
Related Tiotropium Standards
- Tiotropium Bromide Impurity 14 (CAS 61616-97-5)
- Tiotropium Impurity 41 (CAS CATO-C4X-176441)
- Tiotropium impurity 48 (CAS CATO-C4X-176448)
- Tiotropium impurity 50 (CAS CATO-C4X-176450)
- Tiotropium impurity 42 (CAS 2512209-13-9)
- Tiotropium Bromide EP Impurity E; (CAS 26447-85-8)
- Tiotropium Impurity 27 (CAS 3140-93-0)
- Tiotropium EP Impurity A (CAS 4746-63-8)
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