Afatinib Impurity 1 CAS 314771-88-5
| CAS No. | 314771-88-5 |
| Molecular Formula | C18H14ClFN4O4 |
| Molecular Weight | 404.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Afatinib Impurity 1 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Afatinib Impurity 1 (CAS 314771-88-5) is a certified pharmaceutical impurity reference standard with the molecular formula C18H14ClFN4O4 and a molecular weight of 404.78 g/mol.
Afatinib Impurity 1 (C18H14ClFN4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Afatinib Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H14ClFN4O4 |
| Molecular Weight | 404.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Afatinib Standards
- Afatinib Impurity 59 (CAS CATO-C4X-100659)
- Afatinib Impurity 66 (CAS CATO-C4X-100666)
- Afatinib Impurity 25 (CAS CATO-C4X-100625)
- Afatinib Impurity 27 (CAS CATO-C4X-100627)
- Afatinib Impurity 32 (CAS 2170273-17-1)
- Afatinib Impurity 30 (CAS CATO-C4X-100630)
- Afatinib Impurity 60 (CAS CATO-C4X-100660)
- Afatinib Impurity 61 (CAS CATO-C4X-100661)
Recommended Standards
- (R)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine (CAS 402855-07-6)
- 5-Chloro-1-methyl-4-(((perfluorophenyl)thio)methyl)-3-phenyl-1H-pyrazole (CAS 956949-82-9)
- 2-((2-Chloro-5-(trifluoromethyl)phenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate (CAS 479378-61-5)
- 1,3-O-Bis(triisopropylsilyl) Glycerol (CAS 98264-26-7)
- Piperacillin impurity 98 (CAS CATO-C4X-173298)
- Relugolix Impurity 171 (CAS CATO-C4X-2429171)
- Cephalexin Impurity 36 (CAS CATO-C4X-126136)
- 6-Iodo-2,4,8-trimethylquinoline (CAS 1935598-72-3)
- 6-((4-Chlorophenyl)amino)-3-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one (CAS 86831-75-6)
- (Z)-Octadec-9-en-1-yl (R,Z)-12-hydroxyoctadec-9-enoate (CAS 36781-75-6)
- Tert-butyl n-(dimethyl-1,3-thiazol-5-yl)carbamate (CAS 1376373-18-0)
- 4-Methyl-N-(pent-1-en-3-yl)benzenesulfonamide (CAS 124070-39-9)
- N,3,4-trimethoxy-N-methylbenzamide (CAS 155586-38-2)
- Semaglutide impurity 80 (CAS CATO-C4X-222680)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com