Afatinib Impurity 2 CAS 314771-76-1
| CAS No. | 314771-76-1 |
| Molecular Formula | C18H16ClFN4O2 |
| Molecular Weight | 374.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Afatinib Impurity 2 (CAS 314771-76-1, C18H16ClFN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C18H16ClFN4O2, Afatinib Impurity 2 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 374.80 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H16ClFN4O2 |
| Molecular Weight | 374.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Afatinib Standards
- Afatinib Impurity 21 (CAS 402855-03-2)
- Afatinib Impurity 58 (CAS CATO-C4X-100658)
- Afatinib Impurity 62 (CAS CATO-C4X-100662)
- Afatinib Impurity 55 (CAS CATO-C4X-100655)
- Afatinib impurity 42 (CAS CATO-C4X-100642)
- Afatinib Impurity 73 (CAS CATO-C4X-100673)
- Afatinib Impurity 82 (CAS CATO-C4X-100682)
- Afatinib Impurity 69 (CAS CATO-C4X-100669)
Recommended Standards
- tert-Butyl (3-chloro-5-cyano-6-fluoro-9H-pyrido[2,3-b]indol-8-yl)(methyl)carbamate (CAS 2245358-51-2)
- N-(4-chlorophenyl)-3-(2-nitrophenoxy)thiophene-2-carboxamide (CAS 252027-03-5)
- Methyl 1-(4-chlorophenyl)-6-oxo-4-(pyrimidin-2-ylthio)-1,6-dihydropyridazine-3-carboxylate (CAS 338756-23-3)
- N-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}ethyl)-4-methylbenzamide (CAS 1043106-60-0)
- Nicotinic Acid EP Impurity E (CAS 55-22-1)
- Thioctic Acid Impurity 24 (CAS CATO-C4X-152653)
- Palbociclib Impurity 2 (CAS 1072-97-5)
- 5-Methyl-2-hexanol (CAS 627-59-8)
- 2-(1-[(tert-Butoxy)carbonyl]hydrazin-1-yl)ethan-1-ol (CAS 114897-60-8)
- N-Cbz-N'-tert-Butyl-DL-phenylglycinamide (CAS 1400644-17-8)
- 2-Fluoro-5-methoxynicotinaldehyde (CAS 1227597-35-4)
- 4,6-Dichloropyrrolo[1,2-b]pyridazine-3-carboxylic acid (CAS 1416440-30-6)
- 3-Cyclopropoxy-2-methylpyridine-4-sulfonamide (CAS 1243411-64-4)
- Peptide YY (human) trifluoroacetate salt (CAS 118997-30-1)
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