Afatinib Impurity 66 CAS CATO-C4X-100666
| CAS No. | CATO-C4X-100666 |
| Molecular Formula | C18H16ClFN4O4 |
| Molecular Weight | 406.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Afatinib Impurity 66 (C18H16ClFN4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Afatinib Impurity 66 (CAS CATO-C4X-100666), a pharmacopoeial impurity reference standard (molecular formula C18H16ClFN4O4, MW 406.80 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Afatinib Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H16ClFN4O4 |
| Molecular Weight | 406.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Afatinib Standards
- Afatinib Impurity 1 (CAS 314771-88-5)
- Afatinib Impurity 59 (CAS CATO-C4X-100659)
- Afatinib Impurity 27 (CAS CATO-C4X-100627)
- Afatinib Impurity 32 (CAS 2170273-17-1)
- Afatinib Impurity 30 (CAS CATO-C4X-100630)
- Afatinib Impurity 25 (CAS CATO-C4X-100625)
- Afatinib Impurity 60 (CAS CATO-C4X-100660)
- Afatinib Impurity 61 (CAS CATO-C4X-100661)
Recommended Standards
- 1,3-Dibromo-2-iodo-5-nitrobenzene (CAS 98137-96-3)
- 2-(4-Chlorobenzenesulfonamido)-N-[3-(trifluoromethyl)phenyl]propanamide (CAS 1008261-45-7)
- N-(6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}pyridin-2-yl)-4-methylbenzamide (CAS 477854-90-3)
- 2-(4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)benzo[d]thiazole (CAS 1023553-54-9)
- Mirogabalin Impurity 114 (CAS CATO-C4X-2924114)
- Dutasteride EP Impurity A (CAS 104239-97-6)
- Halometasone Impurity 6 (CAS CATO-C4X-14466)
- 2-Amino-2-methyl-3-(methylthio)propanenitrile hydrochloride (CAS 1803593-45-4)
- 5-Chloro-6-hydroxypyridine-3-sulfonic acid (CAS 1279219-02-1)
- Risperidone Impurity 31 (CAS 66698-27-9)
- Ethyl 2-((3,4-dichlorophenyl)thio)-2-oxoacetate (CAS 1443342-13-9)
- 2-(Anthracene-2-sulfonamido)acetic acid (CAS 63553-68-4)
- 1-Fluoro-3-(triethoxymethyl)benzene (CAS 32347-94-7)
- Liraglutide Impurity 19 TFA Salt (CAS CATO-C4X-199219)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com