Etomidate EP Impurity A CAS 3157-27-5
| CAS No. | 3157-27-5 |
| Molecular Formula | C12H12N2O2 |
| Molecular Weight | 216.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 216.24 g/mol gives Etomidate EP Impurity A distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Etomidate EP Impurity A (CAS 3157-27-5) is a certified pharmaceutical impurity reference standard with the molecular formula C12H12N2O2 and a molecular weight of 216.24 g/mol.
Etomidate EP Impurity A (C12H12N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12N2O2 |
| Molecular Weight | 216.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Etomidate Standards
- Etomidate EP Impurity A (CAS 56649-48-0)
- Etomidate EP Impurity A (CAS 7036-56-8)
- (S)-Etomidate EP Impurity A (CAS 56649-49-1)
- Etomidate Impurity 17 (CAS 81591-23-3)
- Etomidate impurity 63 (CAS CATO-C4X-188463)
- Etomidate Impurity 72 (CAS CATO-C4X-188472)
- Etomidate Impurity 24 (CAS CATO-C4X-188424)
- Etomidate Impurity 8 (CAS 66512-37-6)
Recommended Standards
- Pyridoxine impurity 3 (CAS 91446-43-4)
- Phenamacril (CAS 39491-78-6)
- H-β-(2-Quinolyl)-Ala-OH (CAS 161513-46-8)
- Leflunomide EP Impurity G (CAS 724429-16-7)
- (E)-Ramelteon Impurity 11 (CAS 196597-61-2)
- Safinamide Impurity 40 (CAS 33208-99-0)
- Naproxen Impurity 17 (CAS CATO-C4X-170817)
- 5-Amino-1-(4-chlorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS 941868-12-8)
- 2,4-Dichloro-6-nitropyrimidine (CAS 67482-15-9)
- LKX634SL5X 280585-34-4 Oxeglitazar [INN] (2E,4E)-5-(7-Methoxy-3,3-dimethyl-2,3-dihydro-1-benzoxepin-5-yl)-3-methylpenta-2,4-dienoic acid Oxeglitazar UNII-LKX634SL5X (CAS 280585-34-4)
- Trazodone Impurity 70 (CAS CATO-C4X-177270)
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- 3-(8-Methoxy-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylaldehyde (CAS 1562309-96-9)
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