Axitinib Impurity 38 CAS 319472-78-1
| CAS No. | 319472-78-1 |
| Molecular Formula | C7H4I2N2 |
| Molecular Weight | 369.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Axitinib Impurity 38 (CAS 319472-78-1) is a certified pharmaceutical impurity reference standard with the molecular formula C7H4I2N2 and a molecular weight of 369.93 g/mol.
The molecular framework of Axitinib Impurity 38 (C7H4I2N2) is characterized by a nitrile group, iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Axitinib Impurity 38 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4I2N2 |
| Molecular Weight | 369.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 2 |
Related Axitinib Standards
- Axitinib Impurity N3 (CAS 885520-24-1)
- Axitinib Impurity 58 (CAS 3037703-03-7)
- Axitinib Impurity 14 (CAS CATO-C4X-107114)
- Axitinib Impurity 41 (CAS 319462-41-4)
- Axitinib Acid (CAS 319462-34-5)
- Axitinib Impurity 55 (CAS CATO-C4X-107155)
- Axitinib Impurity 77 (CAS CATO-C4X-107177)
- Axitinib Impurity 74 (CAS CATO-C4X-107174)
Recommended Standards
- 2-chloroacetic acid [3-[(2-methylanilino)-oxomethyl]-2-naphthalenyl] ester 35245-26-2 A822672 [3-[(2-methylphenyl)carbamoyl]naphthalen-2-yl] 2-chloranylethanoate (CAS 35245-26-2)
- Chloroprocaine impurity 63 (CAS 2832162-01-1)
- 3,5-Diiodo-1H-indazole (CAS 351456-48-9)
- Tributyltin bromide (CAS 1461-23-0)
- Nafamostat impurity 115 (CAS CATO-C4X-1332115)
- Ezetimibe Impurity 56 (CAS 371-40-4)
- Nintedanib Impurity 101 (CAS CATO-C4X-1814101)
- (S)-4-((tert-Butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-ol (CAS 2248638-09-5)
- 1-Bromo-4-(bromomethyl)-3-fluoro-2-(trifluoromethyl)benzene (CAS 2090979-68-1)
- 1-(3,4-Dihydro-2h-pyran-2-yl)-N-((2-methoxypyridin-3-yl)methyl)methanamine (CAS 1271670-42-8)
- 1-(3-Bromothiophene-2-carbonyl)piperidine-3-carboxamide (CAS 1208725-29-4)
- (3aR,4R,5R,6aS)-4-((R)-3-Hydroxy-5-phenylpentyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate (CAS 145667-74-9)
- 1,2-Dimethoxy-3-vinylbenzene (CAS 17055-36-6)
- Semaglutide impurity 28 (CAS CATO-C4X-222628)
Why CATO?
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