Adenosine Impurity 6 CAS 321-30-2
| CAS No. | 321-30-2 |
| Molecular Formula | 2*C5H5N5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Adenosine Impurity 6 (CAS 321-30-2, C5H5N5H2O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Adenosine Impurity 6 (C5H5N5H2O4S) is characterized by a carbohydrate-derived structure, an amide group, a sulfone group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | 2*C5H5N5 H2O4S |
| Molecular Weight | 233.20 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Adenosine Standards
- 3ʹ-Adenosine phosphate 5ʹ-phosphate sulfate, tetralithium salt (CAS 102029-54-9)
- Adenosine 5-Monophosphoramidate Sodium Salt (CAS 102029-68-5)
- Adenosine 3',5'-cyclic Monophosphate Tris Salt (CAS 102029-77-6)
- Adenosine 5'-diphosphate bis(cyclohexylammonium) salt (CAS 102029-87-8)
- Adenosine 5′-triphosphate di(trihydroxymethylaminomethane) salt hydrate (CAS 102047-34-7)
- Adenosine-5-diphosphoglucose (CAS 102129-65-7)
- Adenosine 5′-(hexahydrogen pentaphosphate), P′′′′→5′-ester with thymidine (CAS 103137-88-8)
- Adenosine Impurity 27 (CAS 103828-77-9)
Recommended Standards
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- Hydantoin Impurity 29 (CAS 4371-32-8)
- Cefpodoxime Proxetil EP Impurity A -d3 Sodium Salt (CAS CATO-C4X-157931)
- O-Methyl-DL-serine Hydrochloride (CAS 2133496-72-5)
- (E)-1-(4-(2-fluorophenyl)piperazin-1-yl)-3-(m-tolyl)prop-2-en-1-one (CAS 329779-85-3)
- 4-Chloro-2-(piperidin-4-yloxy)pyrimidine hydrochloride (CAS 1159823-41-2)
- 6-Bromo-8-fluoroimidazo[1,2-a]pyridine-3-carbonitrile (CAS 1260657-25-7)
- 2-(Chloromethyl)-1-ethyl-5-(morpholine-4-sulfonyl)-1h-1,3-benzodiazole (CAS 785792-29-2)
- 1-Methyl-1H-pyrazolo[3,4-c]pyridin-3-amine (CAS 1557979-67-5)
- Insulin Degludec Impurity 14 (CAS CATO-C4X-215714)
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