Methyl 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylate CAS 321430-51-7
| CAS No. | 321430-51-7 |
| Molecular Formula | C13H14ClF3N2O2 |
| Molecular Weight | 322.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methyl 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylate (CAS 321430-51-7), molecular formula C13H14ClF3N2O2 and molecular weight 322.71 g/mol, is a CATO reference standard with documented purity and traceability.
Methyl 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylate (C13H14ClF3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H14ClF3N2O2 |
| Molecular Weight | 322.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Methyl Standards
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- 1-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)piperidine-4-carboxylic acid (CAS 1311279-30-7)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carbohydrazide (CAS 321430-54-0)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl acetate (CAS 321430-31-3)
- 1-[5-Chloro-2-nitro-4-(trifluoromethyl)phenyl]azepane (CAS 646456-34-0)
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Recommended Standards
- Ethyl 5-(chloromethyl)-1-[4-(1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-yl]-1H-1,2,3-triazole-4-carboxylate (CAS 681851-71-8)
- N-(2-chloro-5-(trifluoromethyl)phenyl)-2-morpholinoacetamide (CAS 297150-40-4)
- 5-(4-Chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole (CAS 586333-28-0)
- 318288-86-7 4-(3-chlorophenyl)-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole KS-000039D1 (CAS 318288-86-7)
- 2-Amino-3,5-dimethylbenzyl Alcohol (CAS 873388-89-7)
- 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (CAS 1019056-31-5)
- 2-Bromo-3-(4-(trifluoromethyl)phenyl)propanoic acid (CAS 1420794-20-2)
- 9,10,12,13,15,16-Hexabromooctadecanoic acid (CAS 4167-08-2)
- Rac-2-[(1R,2R)-2-{[(tert-butoxy)carbonyl]amino}cyclohexyl]acetic acid (CAS 143617-91-8)
- (3,5-Bis(trifluoromethyl)phenyl)diphenylphosphine oxide (CAS 299176-62-8)
- Ethyl 2-methyl-3-oxo-3-(phenylamino)propanoate (CAS 52629-26-2)
- Ethyl 3-fluoro-4-iodobutanoate (CAS 1401902-56-4)
- 1-([1,1'-Biphenyl]-2-yl)-3-(1,3-dioxan-2-yl)propan-1-one (CAS 898756-53-1)
- Semaglutide-d8 Tetratrifluoroacetate (CAS CATO-C4X-222617)
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