Tibolone EP Impurity D CAS 32297-45-3
| CAS No. | 32297-45-3 |
| Molecular Formula | C21H28O2 |
| Molecular Weight | 312.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Tibolone EP Impurity D (CAS 32297-45-3), a pharmacopoeial impurity reference standard (molecular formula C21H28O2, MW 312.45 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Tibolone EP Impurity D (C21H28O2) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H28O2 |
| Molecular Weight | 312.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
Related Tibolone Standards
- Tibolone (CAS 5630-53-5)
- Delta-4-Tibolone (CAS 1162-60-3)
- Tibolone impurity 1 (CAS 100239-44-9)
- Tibolone impurity 2 (CAS 100239-45-0)
- Tibolone D5 (CAS CATO-C4X-24034)
- Delta-4-Tibolone-D5 (CAS CATO-C4X-24037)
- Tibolone EP Impurity A (CAS CATO-C4X-240312)
- Tibolone EP Impurity A(10-β-Hydroxy 4-Tibolone) (CAS 105186-35-4)
Recommended Standards
- Promestriene Impurity 7 (CAS 1852-86-4)
- Altrenogest impurity 12 (CAS 23760-34-1)
- Promestriene Impurity 12 (CAS CATO-C4X-220512)
- Altrenogest Impurity 3 (CAS 141299-96-9)
- Atracurium Impurity 53 (CAS 1599467-97-6 (Relative))
- Pregabalin N-Methyl Impurity (CAS 1155843-61-0)
- Abrocitinib Impurity 49 (CAS CATO-C4X-288449)
- (4-Bromophenyl)(2-((4-methylbenzyl)thio)-4,5-dihydro-1H-imidazol-1-yl)methanone (CAS 851805-10-2)
- 2-(3,4-Dihydroxy-5-methoxyphenyl)acetic acid (CAS 2989-10-8)
- Letermovir Impurity 75 (CAS CATO-C4X-291575)
- 3,6-Dibromo-benzo[b]thiophene (CAS 1426082-37-2)
- 2-Bromo-4-(trifluoromethoxy)-6-nitroaniline (CAS 886499-21-4)
- 3-Chloro-n-methyl-n-(trifluoromethyl)aniline (CAS 1420813-08-6)
- Allo-Thr5-Tirzepatide (CAS CATO-CPTD788934)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com