Letrozole Impurity 5 CAS 32446-66-5

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.32446-66-5
Molecular FormulaC15H8N2O
Molecular Weight232.24 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Letrozole Impurity 5 CAS 32446-66-5 chemical structure

Description

CATO supplies Letrozole Impurity 5 (CAS 32446-66-5), a pharmacopoeial impurity reference standard (molecular formula C15H8N2O, MW 232.24 g/mol) used for the identification and quantification of trace impurities in APIs.

Structurally, Letrozole Impurity 5 (C15H8N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 232.24 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Letrozole Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC15H8N2O
Molecular Weight232.24 g/mol
Purity>95%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)13.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1966
Nitrogen Atoms2

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