2-Chloro-6-methoxybenzoic acid CAS 3260-89-7
| CAS No. | 3260-89-7 |
| Molecular Formula | C8H7ClO3 |
| Molecular Weight | 186.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-6-methoxybenzoic acid.
2-Chloro-6-methoxybenzoic acid (CAS 3260-89-7) is a high-purity analytical reference standard with the molecular formula C8H7ClO3 and a molecular weight of 186.59 g/mol.
The molecular framework of 2-Chloro-6-methoxybenzoic acid (C8H7ClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7ClO3 |
| Molecular Weight | 186.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 4-Chloro-2-(hydroxymethyl)benzoic acid (CAS 100448-59-7)
- Methyl 2-Chloro-4-hydroxybenzoate (CAS 104253-44-3)
- 3-Chloro-2,4-dihydroxy-6-methylbenzaldehyde (CAS 106325-72-8)
- 2-Chloro-4-(hydroxymethyl)benzoic acid (CAS 1071989-48-4)
- Methyl 2-chloro-3-hydroxybenzoate (CAS 1125632-11-2)
- 2-Chloro-6-hydroxy-4-methoxybenzaldehyde (CAS 116475-68-4)
- 2-Chloro-3-(hydroxymethyl)benzoic acid (CAS 1187238-13-6)
- 4-Chloro-3-(hydroxymethyl)benzoic acid (CAS 1187238-15-8)
Recommended Standards
- 2-Chloro-5-methoxybenzoic Acid (CAS 6280-89-3)
- 2-Hydroxy-3-methoxybenzoyl chloride (CAS 82944-14-7)
- 2-chloro-5-hydroxy-4-methoxybenzaldehyde (CAS 89938-55-6)
- 2-Methoxyphenyl carbonochloridate (CAS 2293-75-6)
- 2-(3-Fluoropyrrolidin-1-yl)ethan-1-ol (CAS 1824348-92-6)
- 2-(3-Bromo-2-methylphenyl)acetic acid (CAS 1261618-03-4)
- 3-Amino-5-(2-tetrahydrofuryl)pyrazole (CAS 1028843-21-1)
- 4-(chloromethyl)-2-methanesulfonyl-1-methoxybenzene (CAS 1311317-33-5)
- Dihydroxy Moxonidine (CAS 352457-32-0)
- (R)-3-(Dimethylamino)-1-phenylpropan-1-ol oxalate (CAS 1270016-44-8)
- 2-Bromo-4-(chloromethyl)thiazole (CAS 5198-77-6)
- 4-Bromo-3-chloro-2-methylbenzenesulfonyl chloride (CAS 1208075-53-9)
- S-(2-Hydroxypropyl) methanesulfonothioate (CAS 30388-01-3)
- Tirzepatide Impurity 48 (CAS CATO-C4X-324048)
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