Duloxetine Impurity 12 CAS 32634-66-5
| CAS No. | 32634-66-5 |
| Molecular Formula | C20H18O8 |
| Molecular Weight | 386.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Duloxetine Impurity 12 (CAS 32634-66-5) is a certified pharmaceutical impurity reference standard with the molecular formula C20H18O8 and a molecular weight of 386.35 g/mol.
Based on its molecular formula C20H18O8, Duloxetine Impurity 12 contains a flavonoid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 386.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Duloxetine Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H18O8 |
| Molecular Weight | 386.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
Related Duloxetine Standards
- Duloxetine USP Related Compound H (CAS 199191-66-7)
- Duloxetine Impurity 19 (CAS 947686-09-1)
- Duloxetine Impurity 49 (CAS 116817-79-9)
- Duloxetine Impurity 13 (CAS 741693-79-8)
- Duloxetine Impurity 45 (CAS CATO-C4X-133645)
- Duloxetine 4-Hydroxy N-Methyl (CAS 1346601-61-3)
- Duloxetine Impurity (CAS 199191-67-8)
- Duloxetine Impurity (CAS 2680527-91-5)
Recommended Standards
- Tetramethyl [1,1'-biphenyl]-3,3',4,4'-tetracarboxylate (CAS 36978-37-7)
- Rivastigmine USP Related Compound A (CAS 32634-68-7)
- Tetramethyl [1,1'-biphenyl]-2,3,3',4'-tetracarboxylate (CAS 36978-36-6)
- Ketoprofen Impurity 99 (CAS CATO-C4X-147199)
- Palbociclib impurity 131 (CAS CATO-C4X-1125131)
- Parecoxib Impurity 5 (CAS CATO-C4X-15915)
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