Duloxetine USP Related Compound H CAS 199191-66-7
| CAS No. | 199191-66-7 |
| Molecular Formula | C22H23NO4S |
| Molecular Weight | 397.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 397.49 g/mol gives Duloxetine USP Related Compound H distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Duloxetine USP Related Compound H (CAS 199191-66-7), molecular formula C22H23NO4S and molecular weight 397.49 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Duloxetine USP Related Compound H (C22H23NO4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Duloxetine USP Related Compound H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H23NO4S |
| Molecular Weight | 397.49 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2013 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Duloxetine Standards
- Duloxetine Impurity 12 (CAS 32634-66-5)
- Duloxetine Impurity 19 (CAS 947686-09-1)
- Duloxetine Impurity 49 (CAS 116817-79-9)
- Duloxetine Impurity 45 (CAS CATO-C4X-133645)
- Duloxetine Impurity (CAS 199191-67-8)
- Duloxetine Impurity 13 (CAS 741693-79-8)
- Duloxetine 4-Hydroxy N-Methyl (CAS 1346601-61-3)
- Duloxetine Impurity (CAS 2680527-91-5)
Recommended Standards
- Blonanserin Impurity 41 (CAS CATO-C4X-111041)
- Glipizide EP Impurity C (CAS 13554-93-3)
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- Eletriptan Impurity 2 (CAS CATO-C4X-18872)
- [4-(2,4-dichlorophenyl)oxan-4-yl]methanamine (CAS 1017407-65-6)
- 2-Chloro-N-cyclopropyl-4-fluoro-N-((1-methyl-1H-pyrrol-2-yl)methyl)benzamide (CAS 1286705-02-9)
- Methyl 8-hydroxy-2-oxo-1-azaspiro[4.5]Dec-7-ene-7-carboxylate (CAS 749861-28-7)
- methyl 4-chloro-1-(chloromethyl)-1H-pyrazole-3-carboxylate (CAS 1170168-55-4)
- Fosaprepitant Impurity 48 (CAS 1707-92-2)
- (S)-1-Amino-2,3-dihydro-1H-inden-4-ol (CAS 1201364-15-9)
- Bromhexine Impurity 19 (CAS CATO-C4X-106019)
- 3-(4-Ethoxyphenoxy)-2,2-dimethylpropan-1-amine (CAS 1225686-05-4)
- Methyl 4-chloro-3-(trifluoromethoxy)benzoate (CAS 1261444-00-1)
- Semaglutide impurity 104(Fmoc-D-His-Aib) (CAS 2171211-18-8)
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