Orforglipron impurity 27 CAS 465529-57-1
| CAS No. | 465529-57-1 |
| Molecular Formula | C8H7BrN2 |
| Molecular Weight | 211.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Orforglipron impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Orforglipron impurity 27 (CAS 465529-57-1, C8H7BrN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Orforglipron impurity 27 (C8H7BrN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H7BrN2 |
| Molecular Weight | 211.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Orforglipron Standards
- Orforglipron impurity 33 (CAS CATO-C4X-323433)
- Orforglipron impurity 127 (CAS 2203400-61-5)
- Orforglipron Impurity 115 (CAS CATO-C4X-3234115)
- Orforglipron Impurity 63 (CAS 2212021-57-1)
- Orforglipron impurity 22 (CAS 3047293-07-9)
- Orforglipron Impurity 40 (CAS CATO-C4X-323440)
- Orforglipron Impurity 53 (CAS CATO-C4X-323453)
- Orforglipron impurity 35 (CAS 7254-19-5)
Recommended Standards
- 4-Bromo-3-Methyl-1H-Pyrrolo[2,3-c]Pyridine (CAS 1639444-93-1)
- alpha-Bromocinnamaldehyde (CAS 5443-49-2)
- CAS 88525-80-8 (CAS 88525-80-8)
- 1223748-49-9 5-chloro-4-(chloromethyl)thiophene-2-carboxylic acid 5-chloro-4-(chloromethyl)thiophene-2-carboxylicacid A11405 (CAS 1223748-49-9)
- Orforglipron impurity 36 (CAS 1092961-07-3)
- Atosiban Impurity 13 (CAS CATO-C4X-229313)
- Telmisartan Impurity 48 (CAS 623-09-6)
- (3-Amino-5-chlorophenyl)boronic acid (CAS 1186403-18-8)
- 1-Benzyl-4-(4-methoxyphenoxy)phthalazine (CAS 338404-26-5)
- 2,2,2-trifluoro-1-[3-(4-pyridyl)imidazo[1,5-a]pyridin-1-yl]ethanone (CAS 1797984-04-3)
- 2-Chloro-N-(3-(5,7-dimethylbenzo[d]oxazol-2-yl)-2-methylphenyl)-4-methylbenzamide (CAS 590395-96-3)
- 6-Methoxy-4a,8a-dihydroquinazolin-4(3H)-one (CAS 1841081-80-8)
- 5-ethyl-1-[4-(propan-2-yloxy)phenyl]-1H-1,2,3-triazole-4-carboxylic acid (CAS 1096911-94-2)
- Semaglutide impurity 54 (CAS CATO-C4X-222654)
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