3,5-Bis(trifluoromethyl)chlorobenzene CAS 328-72-3
| CAS No. | 328-72-3 |
| Molecular Formula | C8H3ClF6 |
| Molecular Weight | 248.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3,5-Bis(trifluoromethyl)chlorobenzene (CAS 328-72-3), molecular formula C8H3ClF6 and molecular weight 248.55 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C8H3ClF6, 3,5-Bis(trifluoromethyl)chlorobenzene contains fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 248.55 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3,5-Bis(trifluoromethyl)chlorobenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H3ClF6 |
| Molecular Weight | 248.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Bis Standards
- 2,4-Bis(trifluoromethyl)chlorobenzene 1-chloro-2,4-bis(trifluoromethyl)benzene 1,3-bis(trifluoromethyl)-4-chlorobenzene 1-chloro-2,4-bis-(trifluoromethyl)benzene 2,4-bis-(trifluoromethyl)chlorobenzene 327-76-4 (CAS 327-76-4)
- 2,6-BIS(TRIFLUOROMETHYL)CHLOROBENZENE 2-CHLORO-1,3-BIS(TRIFLUOROMETHYL)BENZENE 63430-02-4 BENZENE, 2-CHLORO-1,3-BIS(TRIFLUOROMETHYL)- YF10048 (CAS 63430-02-4)
- 4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzoyl chloride (CAS 326923-35-7)
- 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride (CAS 1365939-85-0)
- 1-Methyl-3-(trifluoromethyl)-1h-pyrazole-4-sulfonyl chloride (CAS 519056-67-8)
- 1-Methyl-3-(trifluoromethyl)-1h-pyrazole-5-sulfonyl chloride (CAS 884340-52-7)
- 5-Methyl-2-(trifluoromethyl)furan-3-sulfonyl chloride (CAS 306935-02-4)
- 4-(1-(Trifluoromethyl)cyclopropyl)benzoyl chloride (CAS 1431616-45-3)
Recommended Standards
- 2-Chloro-1,4-bis(trifluoromethyl)benzene (CAS 328-91-6)
- 4-Chloro-1,2-bis(trifluoromethyl)benzene (CAS 320-30-9)
- 1-(5-Bromo-2-chlorophenyl)-N,N-dimethylmethanamine (CAS 861967-07-9)
- [(2-Bromo-6-chlorophenyl)methyl](ethyl)amine (CAS 1862910-15-3)
- 2-(5-((Tert-butoxycarbonyl)amino)-6-oxo-2-phenylpyrimidin-1(6H)-yl)acetic acid (CAS 184710-54-1)
- 7-(Hydroxymethyl)-3-methyl-1,5-naphthyridin-2(1H)-one (CAS 2921726-65-8)
- 3-(Piperidin-4-ylmethyl)imidazolidine-2,4-dione (CAS 1083423-88-4)
- 5-Chloro-2-methoxy-3-propoxypyridine (CAS 1228957-11-6)
- (4-(Hexyloxy)phenyl)(oxazol-2-yl)methanone (CAS 898760-29-7)
- 3-(3-Ethyl-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid (CAS 1243102-22-8)
- 2-amino-3-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}propanoic acid (CAS 173203-45-7)
- 4-Amino-5-((2,4-dimethylphenoxy)methyl)-4h-1,2,4-triazole-3-thiol (CAS 117480-89-4)
- 6-Bromo-2-(3-bromophenyl)quinoline-4-carboxylic acid (CAS 350998-36-6)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
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