6-Chloro-2-(4-methoxyphenyl)-1-((3-(trifluoromethyl)benzyl)oxy)-1H-benzo[d]imidazole CAS 329234-91-5
| CAS No. | 329234-91-5 |
| Molecular Formula | C22H16ClF3N2O2 |
| Molecular Weight | 432.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 6-Chloro-2-(4-methoxyphenyl)-1-((3-(trifluoromethyl)benzyl)oxy)-1H-benzo[d]imidazole (C22H16ClF3N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
6-Chloro-2-(4-methoxyphenyl)-1-((3-(trifluoromethyl)benzyl)oxy)-1H-benzo[d]imidazole (CAS 329234-91-5), molecular formula C22H16ClF3N2O2 and molecular weight 432.82 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 6-Chloro-2-(4-methoxyphenyl)-1-((3-(trifluoromethyl)benzyl)oxy)-1H-benzo[d]imidazole under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H16ClF3N2O2 |
| Molecular Weight | 432.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 6-Chloro-2-(4-methoxyphenyl)-1-((4-(trifluoromethyl)benzyl)oxy)-1H-benzo[d]imidazole (CAS 329234-93-7)
- 2-((5-Chloro-2-nitro-4-(trifluoromethyl)phenyl)thio)-N-mesitylacetamide (CAS 217490-34-1)
- 3-Chloro-N-(3-cyano-4-((3-(trifluoromethyl)phenyl)thio)phenyl)benzamide (CAS 477866-68-5)
- (3Z)-3-{[(3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)amino]methylidene}-1,3-dihydro-2-benzofuran-1-one (CAS 337928-55-9)
- 8-Benzyl-4-(4-chloro-2-fluorobenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326813-69-7)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1-methyl-N-(thiophen-2-ylmethyl)-1H-imidazole-5-carboxamide (CAS 339278-18-1)
- 7-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-methyl-2-thioxo-2,3,5,6,7,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(1H)-one (CAS 321430-49-3)
- [4-Chloro-3-(4-ethoxybenzyl)phenyl][(3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methanone (CAS 1103738-30-2)
Recommended Standards
- N-(4-chlorobenzyl)-1-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 400083-05-8)
- Padsevonil (CAS 1294000-61-5)
- N'-[(1E)-{4-[(3-chlorophenyl)methoxy]phenyl}methylidene]-4-(trifluoromethyl)benzohydrazide (CAS 477863-11-9)
- N-[(4-Chlorophenyl)methyl]-5-oxo-2-(trifluoromethyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide (CAS 241126-97-6)
- 3-(4-Ethoxyphenyl)-5-(((2-fluorophenyl)sulfonyl)methyl)-1,2,4-oxadiazole (CAS 1326901-76-1)
- Methyl 2-{1-[(2,4-dichlorophenyl)methyl]-2-oxo-1,2-dihydropyridine-3-amido}benzoate (CAS 338977-61-0)
- 3-Methyl-N-[2-(pyridin-4-yl)pyrimidin-4-yl]butanamide (CAS 81664-83-7)
- 1-(Oxazol-2-yl)nonan-1-one (CAS 898758-39-9)
- 1472-07-7 Methyl (R)-3-phenylbutyrate Methyl (R)-|A-methylhydrocinnamate (CAS 1472-07-7)
- Methyl 4-chloro-1H-pyrrolo[2,3-β]pyridine-2-carboxylate (CAS 871583-23-2)
- trans-3,7-Dimethylocta-1,5-diene-3,7-diol (CAS 51276-34-7)
- Methyl 4-aminocubane-1-carboxylate hydrochloride (CAS 1620821-59-1)
- Tributyl-9,9′-spirobi[9H-fluoren]-2-ylstannane (CAS 2023839-51-0)
- D-Ile12-Tirzepatide (CAS CATO-CPTD788921)
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