N-(4-chloro-3-nitrophenyl)-2-(4-(4-fluorophenyl)piperazin-1-yl)acetamide CAS 329779-14-8
| CAS No. | 329779-14-8 |
| Molecular Formula | C18H18ClFN4O3 |
| Molecular Weight | 392.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies N-(4-chloro-3-nitrophenyl)-2-(4-(4-fluorophenyl)piperazin-1-yl)acetamide (CAS 329779-14-8), a certified reference material (molecular formula C18H18ClFN4O3, MW 392.81 g/mol) for analytical method development and quality control.
N-(4-chloro-3-nitrophenyl)-2-(4-(4-fluorophenyl)piperazin-1-yl)acetamide (C18H18ClFN4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18ClFN4O3 |
| Molecular Weight | 392.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related N Standards
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- N'-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)acetyl)-N,N-dimethylformohydrazonamide (CAS 338979-30-9)
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- N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[(1-naphthylmethyl)amino]acetamide (CAS 329779-25-1)
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Recommended Standards
- Sofosbuvir Impurity 85 (CAS 1621160-31-3)
- 2-Bromo-1-(2,5-dibromo-3,6-difluorophenyl)ethan-1-one (CAS 1804938-09-7)
- 2-(4-Chlorophenyl)-1-{[3-(trifluoromethyl)phenyl]methanesulfonyl}propan-2-ol (CAS 339276-81-2)
- N-(4-chlorophenyl)-4-(4-fluoro-5-methyl-2-nitrophenyl)piperazine-1-carboxamide (CAS 1262222-58-1)
- 2-(4-Ethynylphenoxy)acetic acid (CAS 29171-45-7)
- 2-(Methylsulfonyl)ethanamine (CAS 49773-20-8)
- 2-((4-Chloronaphthalen-1-yl)oxy)-4-methylaniline (CAS 946729-16-4)
- (+)-Aphidicolin (CAS 38966-21-1)
- 2-(Chloromethyl)-7-methoxybenzo[d]oxazole (CAS 1806304-38-0)
- 1-Acetyl-5-bromo-4-chloro-pseudoindoxyl (CAS 116270-39-4)
- 2-(4-Methoxybenzyl)succinic acid (CAS 956-41-2)
- 1-((2-Nitrophenyl)sulfonyl)piperidine-3-carboxylic acid (CAS 321970-58-5)
- 4-(2,5-Dimethoxybenzoyl)benzoic acid (CAS 93012-66-9)
- Semaglutide impurity 86 (CAS CATO-C4X-222686)
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