Sofosbuvir Impurity 85 CAS 1621160-31-3
| CAS No. | 1621160-31-3 |
| Molecular Formula | C20H18ClFO5 |
| Molecular Weight | 392.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sofosbuvir Impurity 85 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Sofosbuvir Impurity 85 (CAS 1621160-31-3), a pharmacopoeial impurity reference standard (molecular formula C20H18ClFO5, MW 392.81 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Sofosbuvir Impurity 85 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 392.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H18ClFO5 |
| Molecular Weight | 392.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
Related Sofosbuvir Standards
- Sofosbuvir Impurity 68 (CAS 1496551-65-5)
- Sofosbuvir Impurity 95 (CAS CATO-C4X-105295)
- Sofosbuvir Impurity 84 (CAS 914912-69-9)
- Sofosbuvir Impurity 51 (CAS 1233335-78-8)
- Sofosbuvir Impurity 1 (CAS 1033394-94-3)
- Sofosbuvir Impurity 105 (CAS 1946820-91-2)
- Sofosbuvir Impurity 2 (CAS 1157884-58-6)
- Sofosbuvir Impurity 3 (CAS CATO-C4X-10523)
Recommended Standards
- N-(4-chloro-3-nitrophenyl)-2-(4-(4-fluorophenyl)piperazin-1-yl)acetamide (CAS 329779-14-8)
- 2-Bromo-1-(2,5-dibromo-3,6-difluorophenyl)ethan-1-one (CAS 1804938-09-7)
- N'-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)acetyl)-N,N-dimethylformohydrazonamide (CAS 338979-30-9)
- 2-(4-Chlorophenyl)-1-{[3-(trifluoromethyl)phenyl]methanesulfonyl}propan-2-ol (CAS 339276-81-2)
- Raloxifene Impurity N65 (CAS 63675-73-0)
- Baricitinib Impurity 48 (CAS CATO-C4X-226048)
- Bezafibrate Impurity 9 (CAS 84491-96-3)
- H-Pro-Leu-Gly-pNA (CAS 219138-16-6)
- 3-cyclopropyl-3-methylbutanoic acid (CAS 1021939-05-8)
- 4-Ethyl-7-hydroxyisobenzofuran-1(3H)-one (CAS 62596-60-5)
- 5,8-Diphenylquinoxaline (CAS 919282-34-1)
- 2-(3-Bromo-5-methylthiophen-2-yl)ethan-1-amine (CAS 1482960-22-4)
- ON-123300 (CAS 1357470-29-1)
- Des-[Oct-γ-Glu-AEEA-AEEA]-Semaglutide (CAS CATO-C4X-2226112)
Why CATO?
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