N-(4-Chloro-3-nitrophenyl)-2-[4-(3-chlorophenyl)piperazin-1-yl]acetamide CAS 329779-16-0
| CAS No. | 329779-16-0 |
| Molecular Formula | C18H18Cl2N4O3 |
| Molecular Weight | 409.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-(4-Chloro-3-nitrophenyl)-2-[4-(3-chlorophenyl)piperazin-1-yl]acetamide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N-(4-Chloro-3-nitrophenyl)-2-[4-(3-chlorophenyl)piperazin-1-yl]acetamide (CAS 329779-16-0), molecular formula C18H18Cl2N4O3 and molecular weight 409.27 g/mol, is a CATO reference standard with documented purity and traceability.
N-(4-Chloro-3-nitrophenyl)-2-[4-(3-chlorophenyl)piperazin-1-yl]acetamide (C18H18Cl2N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(4-Chloro-3-nitrophenyl)-2-[4-(3-chlorophenyl)piperazin-1-yl]acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18Cl2N4O3 |
| Molecular Weight | 409.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
- n-(2,3-Dichlorophenyl)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetamide (CAS 851720-29-1)
- Metrafenone (CAS 220899-03-6)
- N-(2-(3,5-Dichlorophenyl)-5-phenyl-2H-1,2,3-triazol-4-yl)benzamide (CAS 830336-20-4)
- 4-Bromo-1-methyl-5-((naphthalen-2-yloxy)methyl)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (CAS 1022545-28-3)
- 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(((2R,3S,4S,5R)-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-yl)methyl)acetamide (CAS 118377-57-4)
- 1-(4-chlorophenyl)-6-oxo-N-phenyl-4-(trifluoromethyl)-1,6-dihydro-3-pyridazinecarboxamide 477854-88-9 KS-00002ZS7 (CAS 477854-88-9)
- (3-Chloro-4-(2-(diethylamino)ethoxy)phenyl)boronic acid (CAS 1704080-93-2)
- 1-chloromethanesulfonyl-4-fluoro-benzene (CAS 433-13-6)
- Lafutidine Impurity 8 (CAS CATO-C4X-14768)
- (S)-4-Benzyl-3-(3-(2,3-dihydro-1H-inden-2-yl)propanoyl)oxazolidin-2-one (CAS 1802079-06-6)
- 4-Chloroisoquinoline-8-carboxylic acid (CAS 1823324-56-6)
- 1,4,7-Trichlorodibenzofuran (CAS 83704-41-0)
- N-(4-fluorobenzyl)-4-(2-methylbenzoyl)-1H-pyrrole-2-carboxamide (CAS 478249-39-7)
- Liraglutide Impurity 19 TFA Salt (CAS CATO-C4X-199219)
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