2-Amino-4-(3,4-difluorophenyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile CAS 331977-28-7
| CAS No. | 331977-28-7 |
| Molecular Formula | C19H10F2N2O3 |
| Molecular Weight | 352.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Amino-4-(3,4-difluorophenyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile.
2-Amino-4-(3,4-difluorophenyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile (CAS 331977-28-7), molecular formula C19H10F2N2O3 and molecular weight 352.29 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C19H10F2N2O3, 2-Amino-4-(3,4-difluorophenyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 352.29 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H10F2N2O3 |
| Molecular Weight | 352.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
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- 3-((6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-2-yl)thio)propanenitrile (CAS 148527-87-1)
- (4-Amino-7-fluorocinnolin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl)methanone (CAS 187231-58-9)
- 2-Amino-4-(2-butoxyphenyl)-7-methyl-5-oxo-4H,5H-pyrano[3,2-c]pyran-3-carbonitrile (CAS 371207-99-7)
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Recommended Standards
- (5-Bromo-2-((2-((dimethylamino)methyl)phenyl)thio)phenyl)methanol (CAS 222021-57-0)
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- 6-Fluoro-3-[(6-fluoro-4-hydroxyquinolin-3-yl)carbonyl]quinolin-4-ol (CAS 1864072-59-2)
- 4-Methylumbelliferyl-alfa-L-Iduronide (CAS 66966-09-4)
- 4-Bromo-2,6-difluorobenzonitrile (CAS 123843-67-4)
- N-(4,6-diaminopyrimidin-5-yl)formamide Hydrochloride (CAS 753504-19-7)
- 1-(4-Bromo-2-chloro-5-fluorophenyl)-1H-imidazole (CAS 1809158-00-6)
- 1-[4-(iodomethyl)-1-piperidyl]ethanone (CAS 1353954-96-7)
- 2-Methyl-3-phenylfuran (CAS 50552-26-6)
- Sodium 4-Hydroxybenzoate (CAS 114-63-6)
- 6-Oxaspiro[3.5]nonan-2-one (CAS 2386846-79-1)
- 2-((5-((4-Fluorobenzyl)thio)-1,3,4-thiadiazol-2-yl)thio)acetamide (CAS 477329-72-9)
- (6-Amino-3-chloropyridin-2-yl)methanol (CAS 1333779-89-7)
- (Glu9)-Exenatide (2-39) trifluoroacetate salt (CAS 196109-34-9)
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