Diltiazem Hydrochloride CAS 33286-22-5
| CAS No. | 33286-22-5 |
| Molecular Formula | C22H26N2O4S |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Diltiazem Hydrochloride is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Diltiazem Hydrochloride (CAS 33286-22-5) is a high-purity analytical reference standard with the molecular formula C22H26N2O4SHCl and a molecular weight of 450.98 g/mol.
Diltiazem Hydrochloride (C22H26N2O4SHCl) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H26N2O4S HCl |
| Molecular Weight | 450.98 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Diltiazem Standards
- Diltiazem EP Impurity A HCl (CAS 103532-27-0)
- Diltiazem EP Impurity A HCl (CAS 111188-71-7(free base))
- Diltiazem D4 (CAS 112259-41-3)
- Diltiazem USP Related Compound H HCl (CAS 115992-91-1(Free Base))
- Diltiazem EP Impurity H HCl (CAS 115992-91-1(free base))
- Diltiazem Impurity 9 (CAS 116050-35-2)
- Diltiazem Impurity 23 (CAS 119009-50-6)
- Diltiazem-d3 Hydrochloride (CAS 1217623-80-7)
Recommended Standards
- (Butan-2-yl)[(2e)-2-methyl-3-phenylprop-2-en-1-yl]amine hydrochloride (CAS 1240591-04-1)
- 1-(difluoromethyl)-1H-pyrazol-3-amine hydrochloride (CAS 919785-20-9)
- N-((1-Ethyl-3-methyl-1H-pyrazol-4-yl)methyl)-3-methoxy-1-methyl-1H-pyrazol-4-amine hydrochloride (CAS 1856058-55-3)
- ((1R,2R)-2-Pentylcyclopropyl)boronic acid (CAS 294202-37-2)
- 3-(4-Benzylidene-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)-2-ethylquinazolin-4(3H)-one (CAS 114496-26-3)
- 1-Methyl-N-(2-methylbutyl)piperidin-4-amine (CAS 1096840-55-9)
- 2-(((3-(Aziridin-1-yl)propanoyl)oxy)methyl)-2-ethylpropane-1,3-diyl bis(3-(aziridin-1-yl)propanoate) (CAS 52234-82-9)
- (1-(4-Methoxybenzyl)cyclopropyl)methanamine hydrochloride (CAS 1439903-04-4)
- Methyl 1-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-5-methyl-1H-pyrazole-3-carboxylate (CAS 1263212-05-0)
- Serpent Peptide 2AcOH (CAS 823202-99-9(free base))
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