Ceftizoxime Impurity 8 CAS 33477-97-3
| CAS No. | 33477-97-3 |
| Molecular Formula | C15H14N2O4S |
| Molecular Weight | 318.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Ceftizoxime Impurity 8 (CAS 33477-97-3, C15H14N2O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Ceftizoxime Impurity 8 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 318.35 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C15H14N2O4S |
| Molecular Weight | 318.35 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Ceftizoxime Standards
- Ceftizoxime Impurity 81 (CAS CATO-C4X-179381)
- Ceftizoxime Impurity 87 (CAS CATO-C4X-179387)
- Ceftizoxime Impurity 11(E-isomer) (CAS 1684396-27-7)
- Ceftizoxime Impurity 74(isomers mixture) (CAS 94088-75-2)
- Ceftizoxime Impurity 60 (CAS CATO-C4X-179360)
- (Z)-Ceftizoxime Impurity 22 (CAS CATO-C4X-179322)
- (Z)-Ceftizoxime Impurity 52 (CAS CATO-C4X-179352)
- Ceftizoxime Impurity 65 (CAS CATO-C4X-179365)
Recommended Standards
- Albendazole impurity 34 (CAS CATO-C4X-153534)
- Atosiban Impurity 54 (CAS 1227206-06-5)
- Palbociclib Impurity 45 (CAS 1439-36-7)
- 2,2＇-(2,5-Thiophenediyl)Bis-Benzoxazole (CAS 2866-43-5)
- Alectinib Impurity 32 (CAS CATO-C4X-283632)
- Rosuvastatin Impurity 251 (CAS 1416000-51-5)
- Propofol Impurity 60 (CAS CATO-C4X-147360)
- Selegiline EP Impurity E (CAS 4528-51-2)
- (R)-1-(4-(tert-butyl)phenyl)butan-1-amine (CAS 1213008-52-6)
- 2-(3-Fluoro-4-nitrophenyl)ethan-1-ol (CAS 1637714-63-6)
- 5-Heptyl-2-(4-(pentyloxy)phenyl)pyrimidine (CAS 57202-36-5)
- Valproate EP Impurity J (CAS 5340-48-7)
- 3,5-Di-tert-butyl-4-methylphenol (CAS 950-56-1)
- Ginseng Tetrapeptide (CAS 178553-95-2)
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