Papaverine Impurity 12 CAS 33520-96-6（free base）
| CAS No. | 33520-96-6（free base） |
| Molecular Formula | C20H21NO5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Papaverine Impurity 12 (C20H21NO5HCl) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Papaverine Impurity 12 (CAS 33520-96-6（free base）) is a certified pharmaceutical impurity reference standard with the molecular formula C20H21NO5HCl and a molecular weight of 391.85 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Papaverine Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H21NO5 HCl |
| Molecular Weight | 391.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Papaverine Standards
- Papaverine-d3 Hydrochloride (CAS 113718-66-4)
- Papaverine Impurity 37 (CAS 1207386-32-0)
- Papaverine Hydrochloride - Impurity E (CAS 13074-31-2)
- Papaverine EP Impurity F (CAS 139-76-4)
- Papaverine Impurity 35 (CAS 16637-56-2)
- Papaverine Impurity 14 Hcl (CAS 18694-10-5（free base）)
- Papaverine Impurity 17 (CAS 18783-43-2)
- Papaverine Impurity 2 (CAS 18813-60-0)
Recommended Standards
- Sildenafil impurity 249 (CAS CATO-C4X-1128249)
- Rifapentine Impurity 8 (CAS CATO-C4X-19598)
- Vonoprazan Impurity 160 (CAS 2514735-12-5)
- (R)-4-((benzyloxy)carbonyl)morpholine-2-carboxylic acid (CAS 2287236-97-7)
- Isavuconazole impurity 78 (CAS CATO-C4X-1236178)
- (S)-Benzyl 2-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate (CAS 1420478-89-2)
- 2-(Ethylsulfanyl)-1-methyl-1H-imidazole-5-carbaldehyde N-(4-fluorophenyl)hydrazone (CAS 477854-43-6)
- N-(6-Acetyl-4-methoxypyridin-2-yl)acetamide (CAS 1393576-94-7)
- 2-Amino-5-chloro-3-methylbenzamide (CAS 1006619-83-5)
- Semaglutide Impurity 190 (CAS CATO-C4X-2226190)
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