Adapalene Impurity 4 CAS 33626-98-1
| CAS No. | 33626-98-1 |
| Molecular Formula | C12H9BrO2 |
| Molecular Weight | 265.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 265.10 g/mol gives Adapalene Impurity 4 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Adapalene Impurity 4 (CAS 33626-98-1, C12H9BrO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H9BrO2, Adapalene Impurity 4 contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 265.10 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Adapalene Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9BrO2 |
| Molecular Weight | 265.10 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Br-containing |
Related Adapalene Standards
- Adapalene Impurity 8 (CAS 107430-57-9)
- Adapalene Impurity 9 (CAS 132292-17-2)
- Adapalene impurity 19 (CAS 726-94-3)
- Adapalene EP Impurity C (CAS 43109-77-9)
- Adapalene impurity 20 (CAS CATO-C4X-180920)
- Adapalene EP Impurity A (CAS 932033-58-4)
- Adapalene Impurity 11 (CAS CATO-C4X-180911)
- Adapalene Impurity 14 (CAS 1036766-56-9)
Recommended Standards
- 3- (3-bromophenoxy) phenol (CAS 32220-68-1)
- Alendronic Acid Impurity 6 (CAS CATO-C4X-22426)
- Methyl 8-bromo-1-naphthoate (CAS 38058-95-6)
- Ethylmercury chloride (CAS 107-27-7)
- Telmisartan Impurity 101 (CAS 1338830-39-9)
- Rosiglitazone Impurity (5-[4-N-(2-Pyridylamino)ethoxy]benzylidene] thiazolidine-2,4-dione) (CAS 643764-88-9)
- Felbinac Trometamol Impurity 5 (CAS CATO-C4X-33685)
- 4-Methyl-1-[4-(piperidin-3-ylmethoxy)benzoyl]-piperidine hydrochloride (CAS 1332531-10-8)
- 2-((1-Methyl-1h-pyrazol-3-yl)amino)benzoic acid (CAS 1518243-22-5)
- 1,2-Di(1H-pyrrol-1-yl)ethane (CAS 87543-15-5)
- 2-(2,6-Dimethyl-phenyl)-oxazole (CAS 1222852-67-6)
- 1-[3-(Trifluoromethyl)phenyl]pent-4-en-1-one (CAS 125996-99-8)
- 2-(1,3-Benzothiazol-2-yl)ethan-1-amine (CAS 82928-10-7)
- Lixisenatide (CAS 320367-13-3（free base）)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com